Results 191 to 200 of about 1,127,640 (282)

False Appearance of Gene–Environment Interactions in Genetic Association Studies

, 2016
Yishan Su, Wen‐Chung Lee
openalex   +1 more source

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

FEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee, Jung Yoon Ho, In Sun Hwang, Youn Jin Choi   +3 more
wiley   +1 more source

High-Dimensional Gene-Environment Interaction Analysis. [PDF]

Annu Rev Stat Appl
Wu M, Li Y, Ma S.
europepmc   +1 more source

HSP70 governs permeability and mechanotransduction in primary human endothelial cells

FEBS Open Bio, EarlyView.
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez, Everton G. Melo, Isadora C. B. Pavan, Percíllia V. S. Oliveira, Luiza B. C. T. Coimbra, Thaís L. S. Araujo   +5 more
wiley   +1 more source

Associations of Romantic Partners' Characteristics with Alcohol Consumption and Binge Drinking: Examining Evidence for Gene-Environment Interaction. [PDF]

Clin Psychol Sci
Stephenson M, Cooke ME, Barr P, Maes HHM, Latvala A, Piirtola M, Silventoinen K, Rose RJ, Kaprio J, Dick D, Salvatore JE.   +10 more
europepmc   +1 more source

Gene X Environment Interactions: Polygenic Scores and the Impact of an Early Childhood Intervention in Colombia

Orazio Attanasio, Gabriella Conti, Pamela Jervis, Costas Meghir, Aysu Okbay   +4 more
openalex   +1 more source

Genetic Factors in Nonsmokers with Age‐Related Macular Degeneration Revealed Through Genome‐Wide Gene‐Environment Interaction Analysis

, 2013
Adam C. Naj, William K. Scott, Monique D. Courtenay, William H. Cade, Stephen G. Schwartz, Jaclyn L. Kovach, Anita Agarwal, Gaofeng Wang, Jonathan L. Haines, Margaret A. Pericak‐Vance   +9 more
openalex   +1 more source

Homologous expression and purification of human HAX‐1 for structural studies

FEBS Open Bio, EarlyView.
This research protocol provides detailed instructions for cloning, expressing, and purifying large quantities of the intrinsically disordered human HAX‐1 protein, N‐terminally fused to a cleavable superfolder GFP, from mammalian cells. HAX‐1 is predicted to undergo posttranslational modifications and to interact with membranes, various cellular ...
Mariana Grieben
wiley   +1 more source

Ethical, Legal, and Social Implications of Gene-Environment Interaction Research. [PDF]

Genet Epidemiol
Calluori S, Heimke KK, Caga-Anan C, Kaufman D, Mechanic LE, McAllister KA.   +5 more
europepmc   +1 more source

Gene-environment interaction study on the polygenic risk score for neuroticism, childhood adversity, and parental bonding. [PDF]

Personal Neurosci, 2023
Klingenberg B, Guloksuz S, Pries LK, Cinar O, Menne-Lothmann C, Decoster J, van Winkel R, Collip D, Delespaul P, De Hert M, Derom C, Thiery E, Jacobs N, Wichers M, Lin BD, Luykx J, van Os J, Rutten BPF.   +17 more
europepmc   +1 more source