Overview of molecular signatures of senescence and associated resources: pros and cons
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas +6 more
wiley +1 more source
Genome-wide association study identified novel loci and gene-environment interaction for refractive error in children. [PDF]
Wang Y +15 more
europepmc +1 more source
Gene-Environment Interaction in Genome-Wide Association Studies [PDF]
Cassandra E. Murcray +2 more
openalex +1 more source
Molecular determinants of signal transduction in tropomyosin receptor kinases
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley +1 more source
Gene-environment interaction modifies the association between hyperinsulinemia and serum urate levels through SLC22A12. [PDF]
Fujii W +8 more
europepmc +1 more source
The oxytocin receptor rs2254298 polymorphism and alcohol withdrawal symptoms: a gene-environment interaction in mood disorders. [PDF]
Shen G +11 more
europepmc +1 more source
Gene–Environment Interaction Effects of Peer Deviance, Parental Knowledge and Stressful Life Events on Adolescent Alcohol Use [PDF]
Megan Cooke +7 more
openalex +1 more source
Day/night variations of myeloid and lymphoid cell subsets in the murine inguinal lymph node
The circadian system is involved in the temporal regulation of the immune system. Our study reveals that two innate immune populations, NKT cells and neutrophils, predominate at the beginning of the day in healthy mice, highlighting how the time of day influences immune responses.
Paula M. Wagner +6 more
wiley +1 more source
Efficient and accurate framework for genome-wide gene-environment interaction analysis in large-scale biobanks. [PDF]
Ma Y, Zhao Y, Zhang JF, Bi W.
europepmc +1 more source

