Results 211 to 220 of about 1,150,120 (282)

Efficient and accurate framework for genome-wide gene-environment interaction analysis in large-scale biobanks. [PDF]

Nat Commun
Ma Y, Zhao Y, Zhang JF, Bi W.
europepmc   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Genome-Wide Meta-Analysis of Joint Tests for Genetic and Gene-Environment Interaction Effects [PDF]

, 2010
Hugues Aschard, Dana B. Hancock, Stephanie J. London, Peter Kraft   +3 more
openalex   +1 more source

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

FEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto   +6 more
wiley   +1 more source

High-Fat Diet-Fed Kcnq1 Mutant Mice Have Reduced Pancreatic β-Cell Mass via Gene-Environment Interaction. [PDF]

Diabetes Metab J
Asahara SI, Inoue H, Ihara Y, Teruyama K, Imai A, Hara C, Hara M, Seike M, Yokoi A, Kido N, Suzuki H, Kanno A, Inaba Y, Watanabe H, Shioi G, Kimura-Koyanagi M, Matsumoto M, Inoue H, Nakayama KI, Ogawa W, Kasuga M, Kido Y.   +21 more
europepmc   +1 more source

Prenatal gene-environment interactions mediate the impact of advanced maternal age on mouse offspring behavior [PDF]

Marta Marlena Ziętek, Aneta Jaszczyk, Adrian Stankiewicz, Silvestre Sampino   +3 more
openalex   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

A Pilot Study of Gene/Gene and Gene/Environment Interactions in Alzheimer Disease [PDF]

, 2010
Nader Ghebranious, Bickol N. Mukesh, Philip F. Giampietro, Ingrid Glurich, Susan F. Mickel, Stephen C. Waring, Catherine A. McCarty   +6 more
openalex   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Many roads to a gene-environment interaction. [PDF]

Am J Hum Genet
Westerman KE, Sofer T.
europepmc   +1 more source