Results 311 to 320 of about 11,841,902 (391)

Not just a by‐product: circular DNA molecules derived from V(D)J recombination are linked to worse prognosis in B‐cell leukemia

Molecular Oncology, EarlyView.
Gao et al. report that circular DNA molecules created as by‐products of V(D)J recombination during lymphocyte maturation (ESCs) can replicate and be retained for much longer than previously thought in healthy cells. In BCP‐ALL cells, increased ESC abundance correlates with a greater chance of relapse likely mediated by their ability to induce genome ...
Davide Pradella, Andrea Ventura
wiley   +1 more source

Genetic Basis of Brugada Syndrome. [PDF]

Biomedicines
Xie X, Chen Y, Li Z, Sun Y, Chen G.
europepmc   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Common food preservatives induce an oxidative stress response in <i>Salmonella enterica</i> serovar Typhimurium. [PDF]

Microbiology (Reading)
Holden ER, Horton JCI, Webber MA.
europepmc   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Pharmaco-Epigenetics and Epigenetic Drugs in Type 2 Diabetes: Can Epigenetics Predict Drug Efficiency? [PDF]

Biomedicines
Mkhize SS, Chuturgoon AA, Ghazi T, Machaba KE.   +3 more
europepmc   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Investigating the mechanism of artemisinin in treating osteoarthritis based on bioinformatics, network pharmacology, and molecular docking. [PDF]

Medicine (Baltimore)
Zhu Y, Zhu Y, Li M, Wang Q, Yu W, Zhao D.   +5 more
europepmc   +1 more source

A genomic-led strategy to anticipate drug safety effects

Ferolito BR, Horimoto AR, Gravel-Pucillo K, Golden DJ, Dashti H, Giambartolomei C, Rasooly D, Matty R, Gaziano L, Tsepilov Y, Costa L, Kosik N, Ioannidis H, Karim M, Winicki G, Hunter F, Langenberg C, Whittaker JC, Million Veteran Program, Cai T, Peloso GM, Zdrazil B, Ghoussaini M, Leach AR, Muralidhar S, Smit IA, Casas JP, Gaziano JM, Cho K, Pereira AC.   +29 more
europepmc   +1 more source

Polymorphism of Melanocortin Receptor Genes-Association with Inflammatory Traits and Diseases. [PDF]

Diseases
Bardhan M, Anand A, Javed A, Chilo MA, Khan N, Garg T, Surana A, Huang H, Samim MM, Suresh V, Khare A, Menon B, Kundu T.   +12 more
europepmc   +1 more source