Results 51 to 60 of about 1,991,092 (312)

Systemic similarity analysis of compatibility drug-induced multiple pathway patterns _in vivo_ [PDF]

, 2008
A major challenge in post-genomic research is to understand how physiological and pathological phenotypes arise from the networks of expressed genes and to develop powerful tools for translating the information exchanged between gene and the organ system
Weida Tong, Yi Wang, Yiyu Cheng, Yongyan Wang, Zhan-jun Zhang, Zhong Wang   +5 more
core   +1 more source

Tcf7l2 plays pleiotropic roles in the control of glucose homeostasis, pancreas morphology, vascularization and regeneration [PDF]

, 2017
Type 2 diabetes (T2D) is a disease characterized by impaired insulin secretion. The Wnt signaling transcription factor Tcf7l2 is to date the T2D-associated gene with the largest effect on disease susceptibility.
Argenton, Francesco, Ek, OLIVIER FREDERIC D, Facchinello, Nicola, Grisan, Enrico, Meyer, Dirk, Mongera, Alessandro, Peers, Bernard, Peron, Margherita, Schiavone, Marco, Schmitner, Nicole, Tarife\uf1o Saldivia, Estefania, Tiso, Natascia   +11 more
core   +3 more sources

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács, Zoltán Köllő, Balázs Gellért Karvaly, Mahmoud Obeidat, Rita Nagy, Péter Hegyi, Brigitta Teutsch, Eszter Tuboly, Miklós Garami   +8 more
wiley   +1 more source

Role for growth regulation by estrogen in breast cancer 1 (GREB1) in hormone-dependent cancers [PDF]

, 2018
Sex hormones play important roles in the onset and progression of several cancers, such as breast, ovarian, and prostate cancer. Although drugs targeting sex hormone function are useful in treating cancer, tumors often develop resistance.
Cheng, Meng, Kommagani, Ramakrishna, Michalski, Stephanie   +2 more
core   +2 more sources

Sirolimus for Extracranial Arteriovenous Malformations: A Scoping Review of the Evidence in Syndromic and Non‐Syndromic Cases

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Arteriovenous malformations (AVMs) are rare, high‐flow, vascular anomalies that can occur either sporadically or as part of a genetic syndrome. AVMs can progress with serious morbidity and even mortality if left unchecked. Sirolimus is an mTOR inhibitor that is effective in low‐flow vascular malformations; however, its role in AVMs is unclear.
Will Swansson, Ingrid Winship, Gary Hammerschlag, Laura Scardamaglia   +3 more
wiley   +1 more source

Early LQT2 Nonsense Mutation Generates N-Terminally Truncated hERG Channels with Altered Gating Properties by the Reinitiation of Translation

, 2012
Mutations in the human ether-a-go-go-related gene (hERG) result in long QT syndrome type 2 (LQT2). The hERG gene encodes a K+ channel that contributes to the repolarization of the cardiac action potential.
Gong, Qiuming, Packer, Jonathan D., Stump, Matthew R., Zhou, Zhengfeng   +3 more
core   +1 more source

Intrinsic noise profoundly alters the dynamics and steady state of morphogen-controlled bistable genetic switches [PDF]

, 2016
During tissue development, patterns of gene expression determine the spatial arrangement of cell types. In many cases, gradients of secreted signaling molecules - morphogens - guide this process.
Briscoe, James, Guerrero, Pilar, Page, Karen, Perez-Carrasco, Ruben   +3 more
core   +5 more sources

Evaluating the Utility of Paired Tumor and Germline Targeted DNA Sequencing for Pediatric Oncology Patients: A Single Institution Report

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate the diagnostic yield and utility of universal paired tumor–normal multigene panel sequencing in newly diagnosed pediatric solid and central nervous system (CNS) tumor patients and to compare the detection of germline pathogenic/likely pathogenic variants (PV/LPVs) against established clinical referral criteria for cancer ...
Natalie Waligorski, Rebecca Ronsley, Shannon M. Stasi, Jeffrey Stevens, Erin R. Rudzinski, Christina M. Lockwood, Sarah E. S. Leary, Bonnie L. Cole, Michelle A. Ting, Vera Paulson   +9 more
wiley   +1 more source

Characterization, inheritance of male sterility and development of male sterile and maintainer lines in ridge gourd (Luffa acutangula (Roxb.) L.)

Journal of Horticultural Sciences, 2022
Two male sterile mutants IIHRRG-12MS (long fruited) and IIHRRG-28MS (medium long fruited) were identified from the ridge gourd germplasm IIHR-12 and IIHR-28 respectively at ICAR-IIHR, Bengaluru.
Varalakshmi B, Rajasekharan P.E.
doaj   +1 more source

Control of flower development in Arabidopsis thaliana by APETALA1 and interacting genes [PDF]

, 1993
Mutations in the APETALA1 gene disturb two phases of flower development, flower meristem specification and floral organ specification. These effects become manifest as a partial conversion of flowers into inflorescence shoots and a disruption of sepal ...
Alvarez, John, Bowman, John L., Meyerowitz, Elliot M., Smyth, David R., Weigel, Detlef   +4 more
core