Results 251 to 260 of about 497,526 (307)
Advanced Science, EarlyView.The PBTN targets GRP78 and, upon X‐ray irradiation, generates ONOO− to induce immunogenic cell death, thereby activating CD8+ T cells and establishing a systemic antitumor immune response. ABSTRACT Nitric oxide (NO) treated radioresistant tumors by relieving hypoxia and blocking DNA repair, but its nonselective toxicity has precluded therapeutic use ...
Wanze Zhang +10 more
wiley +1 more source
A high-throughput, streamlined cloning protocol to generate guide RNAs for CRISPR activation. [PDF]
Front Genome EdZhu S +3 more
europepmc +1 more source
Epigenetic Drift and the Generational Limit of Serial Somatic Cell Nuclear Transfer in Pigs. [PDF]
Animals (Basel)Cheng N +6 more
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Journal of Natural Resources and Life Sciences Education, 2003 The nature of plant genetic engineering requires the production of many copies of the specific gene that is to be inserted into the plant cell. This lesson teaches the utilization of recombinant DNA techniques to isolate and copy a specific gene of interest.
Hain, Patricia, Lee, Don
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Molecular and General Genetics MGG, 1979
In Escherichia coli, the structural gene for purine nucleoside phosphorylase, deoD, is subject to insertional inactivation by prophage lambda. From one such secondary site lambda lysogen, strain SP265, one may isolate deletions that remove all or part of the trpR gene and other genes in the deo-thr sector of the E. coli chromosome.
W, Roeder, R L, Somerville
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In Escherichia coli, the structural gene for purine nucleoside phosphorylase, deoD, is subject to insertional inactivation by prophage lambda. From one such secondary site lambda lysogen, strain SP265, one may isolate deletions that remove all or part of the trpR gene and other genes in the deo-thr sector of the E. coli chromosome.
W, Roeder, R L, Somerville
openaire +2 more sources
Urological Research, 1999
Cancer, including genitourinary malignancy, is a consequence of accumulated genetic aberrations in genes involved in crucial regulatory pathways. The result is a deregulation of cellular behaviour, leading to neoplastic transformation, uncontrolled cell proliferation and acquisition of metastatic ability. The development and perfection of techniques in
D H, Schamhart, A C, Westerhof
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Cancer, including genitourinary malignancy, is a consequence of accumulated genetic aberrations in genes involved in crucial regulatory pathways. The result is a deregulation of cellular behaviour, leading to neoplastic transformation, uncontrolled cell proliferation and acquisition of metastatic ability. The development and perfection of techniques in
D H, Schamhart, A C, Westerhof
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2011
Aggrecan is a large proteoglycan that plays roles in numerous tissues during vertebrate development and adult life. The 6,327-nt chick aggrecan coding sequence had been determined from overlapping clones, but a full-length cDNA, needed for use in transgenic expression studies, had not been constructed. The strategy employed to do so was to generate two
Mauricio, Cortes +3 more
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Aggrecan is a large proteoglycan that plays roles in numerous tissues during vertebrate development and adult life. The 6,327-nt chick aggrecan coding sequence had been determined from overlapping clones, but a full-length cDNA, needed for use in transgenic expression studies, had not been constructed. The strategy employed to do so was to generate two
Mauricio, Cortes +3 more
openaire +2 more sources
2021
The discovery of two naturally occurring biological molecules, plasmid DNA and restriction enzymes, with remarkable properties have made possible the development of methods to isolate and manipulate specific DNA fragments. Through this technology, a DNA fragment, even an entire gene and its controlling elements, can be isolated and rejoined with a ...
openaire +1 more source
The discovery of two naturally occurring biological molecules, plasmid DNA and restriction enzymes, with remarkable properties have made possible the development of methods to isolate and manipulate specific DNA fragments. Through this technology, a DNA fragment, even an entire gene and its controlling elements, can be isolated and rejoined with a ...
openaire +1 more source
2020
From 1999-2003, Oxford GlycoSciences (OGS) ran a successful drug discovery oncology programme to discover small molecule inhibitors of the Heparanase I enzyme (HPSE1). HPSE1 at the time was widely regarded as being the sole mammalian enzyme capable of cleaving Heparan Sulfate (HS).
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From 1999-2003, Oxford GlycoSciences (OGS) ran a successful drug discovery oncology programme to discover small molecule inhibitors of the Heparanase I enzyme (HPSE1). HPSE1 at the time was widely regarded as being the sole mammalian enzyme capable of cleaving Heparan Sulfate (HS).
openaire +2 more sources
2023
The discovery of two naturally occurring biological molecules, plasmid DNA and restriction enzymes, with remarkable properties have made possible the development of methods to isolate and manipulate specific DNA fragments. Through this technology, a DNA fragment, even an entire gene and its controlling elements, can be isolated and rejoined with a ...
openaire +1 more source
The discovery of two naturally occurring biological molecules, plasmid DNA and restriction enzymes, with remarkable properties have made possible the development of methods to isolate and manipulate specific DNA fragments. Through this technology, a DNA fragment, even an entire gene and its controlling elements, can be isolated and rejoined with a ...
openaire +1 more source