Results 101 to 110 of about 316,394 (267)

Successful establishment of chicken primordial germ cell (PGC) lines from the endangered Slovakian indigenous chicken breed: the Oravka

Poultry Science
PGCs offer a viable means for cryobanking both female and male avian genetic material. These early-migrating cells ultimately give rise to eggs and sperm cells, making them valuable for long-term conservation of poultry genetic resources.
Jehan Nayga, Bence Lázár, Arnold Tóth, Mariann Molnár, Maria Teresa Salinas Aponte, Jaromír Vasícek, Andrej Balázi, Jakub Vozaf, Lucia Olexiková, Peter Chrenek, Krisztina Liptói, Elen Gócza, Eszter Várkonyi   +12 more
doaj   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Insights on Zika virus envelope gene conservation in American outbreaks. [PDF]

Braz J Microbiol, 2020
Thomazella MV, Lima Neto QA, Duarte Junior FF, Jorge FA, de Castro Moreira D, Leal Junior AD, Presibella MM, Riediger IN, da Silva RA, de Carvalho IMVG, Bertolini DA.   +10 more
europepmc   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Gene conservation of six Hungarian local chicken breeds maintained in small populations over time. [PDF]

PLoS One, 2020
Palinkas-Bodzsar N, Sztan N, Molnar T, Hidas A.   +3 more
europepmc   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

A yeast model of 5‐oxoproline accumulation reveals a general toleration to 5‐oxoproline

FEBS Open Bio, EarlyView.
Using a yeast model, we show that even high accumulation of 5‐oxoproline causes only mild cellular stress and does not trigger oxidative stress. Instead, cells adapt by activating efflux pumps and diverse protective pathways, suggesting that previously proposed harmful effects of 5‐oxoproline may arise from indirect metabolic imbalances rather than the
Pratiksha Dubey, Vaishnavi Sanjayan, Praveen Singh, Shantanu Sengupta, Anand Kumar Bachhawat   +4 more
wiley   +1 more source

conservation-of-gene-essentiality_SMBE2016.pdf

, 2016
We have used transposon-directed insertion-site sequencing to study the essentiality of genes in 12 strains from Enterobacteriaceae. For this, we have studied different biases that can affect our transposon insertion experiment. After correcting for the biases, we have studied the relation between the essentiality of genes and their conservation.
Ghomi, Fatemeh Ashari, Gardner, Paul
openaire   +1 more source

Phosphate-mobilizing bacterial community structure and mobilization mechanisms in tobacco rhizosphere

Current Research in Microbial Sciences
Phosphorus (P), one of the three primary macronutrients essential for plant growth, predominantly exists in soil as unavailable forms for plant uptake.
Yalong Xu, Liqiang Zhu, Jingjing Li, Fan Zhang, Xiaozhan Qu, Chen Wang, Xueao Zheng, Yixiao Zhang, Peijian Cao, Yan Li, Qiansi Chen   +10 more
doaj   +1 more source