Repeat-Induced Point Mutation and Gene Conversion Coinciding with Heterochromatin Shape the Genome of a Plant-Pathogenic Fungus [PDF]
mBio, 2023 Meiosis is associated with genetic changes in the genome—via recombination, gene conversion, and mutations. The occurrence of gene conversion and mutations during meiosis may further be influenced by the chromatin conformation, similar to the effect of ...
Jovan Komluski +2 more
doaj +2 more sources
High-resolution mapping of heteroduplex DNA formed during UV-induced and spontaneous mitotic recombination events in yeast [PDF]
eLife, 2017 In yeast, DNA breaks are usually repaired by homologous recombination (HR). An early step for HR pathways is formation of a heteroduplex, in which a single-strand from the broken DNA molecule pairs with a strand derived from an intact DNA molecule.
Yi Yin +3 more
doaj +5 more sources
Evolution-guided functional analyses reveal diverse antiviral specificities encoded by IFIT1 genes in mammals [PDF]
eLife, 2016 IFIT (interferon-induced with tetratricopeptide repeats) proteins are critical mediators of mammalian innate antiviral immunity. Mouse IFIT1 selectively inhibits viruses that lack 2'O-methylation of their mRNA 5' caps.
Matthew D Daugherty +3 more
doaj +3 more sources
Patterns of Inter-Chromosomal Gene Conversion on the Male-Specific Region of the Human Y Chromosome [PDF]
Frontiers in Genetics, 2017 The male-specific region of the human Y chromosome (MSY) is characterized by the lack of meiotic recombination and it has long been considered an evolutionary independent region of the human genome.
Beniamino Trombetta +3 more
doaj +3 more sources
The Interspecific Fungal Hybrid
mBio, 2021 Hybridization is an important evolutionary mechanism that can enable organisms to adapt to environmental challenges. It has previously been shown that the fungal allodiploid species Verticillium longisporum, the causal agent of verticillium stem striping
Jasper R. L. Depotter +9 more
doaj +3 more sources
Evolution of host-microbe cell adherence by receptor domain shuffling
eLife, 2022 Stable adherence to epithelial surfaces is required for colonization by diverse host-associated microbes. Successful attachment of pathogenic microbes to host cells via adhesin molecules is also the first step in many devastating infections.
EmilyClare P Baker +6 more
doaj +1 more source
Recombination dynamics of a human Y-chromosomal palindrome:rapid GC-biased gene conversion, multi-kilobase conversion tracts, and rare inversions [PDF]
, 2013 The male-specific region of the human Y chromosome (MSY) includes eight large inverted repeats (palindromes) in which arm-to-arm similarity exceeds 99.9%, due to gene conversion activity.
A Geraldes +52 more
core +14 more sources
Structure and evolutionary history of a large family of NLR proteins in the zebrafish [PDF]
Open Biology, 2016 Multicellular eukaryotes have evolved a range of mechanisms for immune recognition. A widespread family involved in innate immunity are the NACHT-domain and leucine-rich-repeat-containing (NLR) proteins.
Kerstin Howe +8 more
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Frontiers in Microbiology, 2022 Analysis of genome variation provides insights into mechanisms in genome evolution. This is increasingly appreciated with the rapid growth of genomic data.
Weilong Hao
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Ecology and Evolution, 2020 The inverted repeat (IR) lacking clade (IRLC) is a monophyletic group within the Papilionoideae subfamily of Fabaceae where plastid genomes (plastomes) do not contain the large IR typical of land plants.
In‐Su Choi +2 more
doaj +1 more source