Increased mutation and gene conversion within human segmental duplications. [PDF]
Nature, 2023 A study comparing the pattern of single-nucleotide variation between unique and duplicated regions of the human genome shows that mutation rate and interlocus gene conversion are elevated in duplicated regions.
Vollger MR +18 more
europepmc +2 more sources
Phenotype reversion as “natural gene therapy” in Fanconi anemia by a gene conversion event [PDF]
Frontiers in Genetics, 2023 Somatic mosaicism appears as a recurrent phenomenon among patients suffering from Fanconi anemia (FA), but its direct prognostic significance mostly remains an open question.
Ilaria Persico +8 more
doaj +2 more sources
Repeat-Induced Point Mutation and Gene Conversion Coinciding with Heterochromatin Shape the Genome of a Plant-Pathogenic Fungus [PDF]
mBio, 2023 Meiosis is associated with genetic changes in the genome—via recombination, gene conversion, and mutations. The occurrence of gene conversion and mutations during meiosis may further be influenced by the chromatin conformation, similar to the effect of ...
Jovan Komluski +2 more
doaj +2 more sources
Frontiers in Plant Science, 2020 LTR retrotransposons constitute a significant part of plant genomes and their evolutionary dynamics play an important role in genome size changes.
Pavel Jedlicka +2 more
doaj +2 more sources
Characterization of Non-selected Intermolecular Gene Conversion in the Polyploid Haloarchaeon Haloferax volcanii [PDF]
Frontiers in Microbiology, 2021 Gene conversion is defined as the non-reciprocal transfer of genetic information from one site to a homologous, but not identical site of the genome. In prokaryotes, gene conversion can increase the variance of sequences, like in antigenic variation, but
Daniel Wasser +4 more
doaj +2 more sources
Evolution of CCR5 and CCR2 Genes in Bats Showed Multiple Independent Gene Conversion Events [PDF]
Viruses, 2022 Chemokine receptors are an important determinant for the infectiousness of different pathogens, which are able to target the host cells by binding to the extracellular domains of these proteins.
Alexandre P. Fernandes +4 more
doaj +2 more sources
CRISPR/Cas9-induced gene conversion between ATAD3 paralogs [PDF]
HGG Advances, 2022 Paralogs and pseudogenes are abundant within the human genome, and can mediate non-allelic homologous recombination (NAHR) or gene conversion events.
Shira Yanovsky-Dagan +3 more
doaj +2 more sources
The Putative Endonuclease Activity of MutL Is Required for the Segmental Gene Conversion Events That Drive Antigenic Variation of the Lyme Disease Spirochete [PDF]
Frontiers in Microbiology, 2022 The Lyme disease spirochete Borrelia burgdorferi, encodes an elaborate antigenic variation system that promotes the ongoing variation of a major surface lipoprotein, VlsE.
Mildred Castellanos +4 more
doaj +2 more sources
Contribution of the gonococcal NEIS1446-ispD gene conversion to the pathobiology of the Neisseria meningitidis urethritis clade, NmUC [PDF]
Infection and ImmunityOver the last decade, a Neisseria meningitidis (Nm) urethritis-causing clade (NmUC) has emerged to cause clusters of meningococcal urethritis in the United States and globally. One genomic signature of NmUC is the integration of Neisseria gonorrhoeae (Ng)
Emilio I. Rodriguez +3 more
doaj +2 more sources
Chromatin structure regulates gene conversion. [PDF]
PLoS Biology, 2007 Homology-directed repair is a powerful mechanism for maintaining and altering genomic structure. We asked how chromatin structure contributes to the use of homologous sequences as donors for repair using the chicken B cell line DT40 as a model.
W Jason Cummings +5 more
doaj +3 more sources