Results 91 to 100 of about 7,960,154 (346)
Cyclic nucleotide signaling as a drug target in retinitis pigmentosa
FEBS Letters, EarlyView.Disruptions in cGMP and cAMP signaling can contribute to retinal dysfunction and photoreceptor loss in retinitis pigmentosa. This perspective examines the mechanisms and evaluates emerging evidence on targeting these pathways as a potential therapeutic strategy to slow or prevent retinal degeneration.
Katri Vainionpää +2 more
wiley +1 more source
eLife, 2016 IFIT (interferon-induced with tetratricopeptide repeats) proteins are critical mediators of mammalian innate antiviral immunity. Mouse IFIT1 selectively inhibits viruses that lack 2'O-methylation of their mRNA 5' caps.
Matthew D Daugherty +3 more
doaj +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2018 Significance Resistance evolution caused by CRISPR/Cas9 gene-drive systems has a major impact on both the future scientific design of such gene-drive systems and on the politics of regulating experimentation and use of such systems. In our study, we show
Mohammad Karaminejadranjbar +6 more
semanticscholar +1 more source
INFORMATIONAL TRANSFER IN MEIOTIC GENE CONVERSION [PDF]
Proceedings of the National Academy of Sciences, 1969 Aberrant meiotic segregations attributable to intragenic events have been analyzed in an unselected sample of 1611 tetrads from three heteroallelic diploids of Saccharomyces cerevisiae . Reciprocal recombination between alleles accounts for only a minor fraction of the total aberrant tetrads, while the majority ...
R. K. Mortimer, S. Fogel
openaire +3 more sources
FEBS Letters, EarlyView.Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu +17 more
wiley +1 more source
FEBS Letters, EarlyView.Three‐dimensional (3D) biological systems have become key tools in lymphoma research, offering reliable in vitro and ex vivo platforms to explore pathogenesis and support precision medicine. This review highlights current 3D non‐Hodgkin lymphoma models, detailing their features, advantages, and limitations, and provides a broad perspective on future ...
Carla Faria +3 more
wiley +1 more source
G3: Genes, Genomes, Genetics, 2016 Allopolyploidization is a biological process that has played a major role in plant speciation and evolution. Genomic changes are common consequences of polyploidization, but their dynamics over time are still poorly understood. Coffea arabica, a recently
Philippe Lashermes +4 more
doaj +1 more source
Systematic characterization and comparative analysis of the rabbit immunoglobulin repertoire. [PDF]
PLoS ONE, 2014 Rabbits have been used extensively as a model system for the elucidation of the mechanism of immunoglobulin diversification and for the production of antibodies.
Jason J Lavinder +4 more
doaj +1 more source
Evidence for Widespread GC-biased Gene Conversion in Eukaryotes
Genome Biology and Evolution, 2012 GC-biased gene conversion (gBGC) is a process that tends to increase the GC content of recombining DNA over evolutionary time and is thought to explain the evolution of GC content in mammals and yeasts.
Eugénie Pessia +5 more
semanticscholar +1 more source
From omics to AI—mapping the pathogenic pathways in type 2 diabetes
FEBS Letters, EarlyView.Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan +2 more
wiley +1 more source