Results 101 to 110 of about 8,864,769 (383)
Long read sequencing reveals poxvirus evolution through rapid homogenization of gene arrays
eLife, 2018 Poxvirus adaptation can involve combinations of recombination-driven gene copy number variation and beneficial single nucleotide variants (SNVs) at the same loci.
Thomas A Sasani +3 more
doaj +1 more source
A strong deletion bias in nonallelic gene conversion. [PDF]
PLoS Genetics, 2012 Gene conversion is the unidirectional transfer of genetic information between orthologous (allelic) or paralogous (nonallelic) genomic segments. Though a number of studies have examined nucleotide replacements, little is known about length difference ...
Raquel Assis, Alexey S Kondrashov
doaj +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2018 Significance Resistance evolution caused by CRISPR/Cas9 gene-drive systems has a major impact on both the future scientific design of such gene-drive systems and on the politics of regulating experimentation and use of such systems. In our study, we show
Mohammad Karaminejadranjbar +6 more
semanticscholar +1 more source
By dawn or dusk—how circadian timing rewrites bacterial infection outcomes
FEBS Letters, EarlyView.The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo +2 more
wiley +1 more source
eLife, 2016 IFIT (interferon-induced with tetratricopeptide repeats) proteins are critical mediators of mammalian innate antiviral immunity. Mouse IFIT1 selectively inhibits viruses that lack 2'O-methylation of their mRNA 5' caps.
Matthew D Daugherty +3 more
doaj +1 more source
PLoS Genetics, 2013 Among the rare colonizers of heavy-metal rich toxic soils, Arabidopsis halleri is a compelling model extremophile, physiologically distinct from its sister species A. lyrata, and A. thaliana.
M. Hanikenne +6 more
semanticscholar +1 more source
Hematopoietic (stem) cells—The elixir of life?
FEBS Letters, EarlyView.The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo +4 more
wiley +1 more source
BMC Genomics, 2011 Background The total number of miRNA genes in a genome, expression of which is responsible for the miRNA repertoire of an organism, is not precisely known.
Thilakarathne Pushpike J +3 more
doaj +1 more source
Supplementary Methods and Materials from Deletion of the Proline-Rich Region of the Murine Metastasis Susceptibility Gene Brd4 Promotes Epithelial-to-Mesenchymal Transition- and Stem Cell-Like Conversion [PDF]
, 2023 Jude Alsarraj +7 more
openalex +1 more source
Journal of Experimental Medicine, 2003 CD4+CD25+ regulatory T cells (Treg) are instrumental in the maintenance of immunological tolerance. One critical question is whether Treg can only be generated in the thymus or can differentiate from peripheral CD4+CD25− naive T cells.
Wanjun Chen +7 more
semanticscholar +1 more source