Results 131 to 140 of about 8,864,769 (383)

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Plant-RRBS, a bisulfite and next-generation sequencing-based methylome profiling method enriching for coverage of cytosine positions [PDF]

, 2017
Background: Cytosine methylation in plant genomes is important for the regulation of gene transcription and transposon activity. Genome-wide methylomes are studied upon mutation of the DNA methyltransferases, adaptation to environmental stresses or ...
A Akalin, A Meissner, A Verkest, AJ Bewick, AR Elhamamsy, AR Quinlan, B Langmead, Bram Slabbinck, C Becker, CA Ibarra, Cindy Martens, D Meng, D Pignatta, EJ Finnegan, F Johannes, Frederik Coppens, G Gremme, H Parkinson, H Saze, H Schöb, H Stroud, H Zhang, H-Q Wang, HJ Xie, International Rice Genome Sequencing Project, J Du, J Yu, JI Gent, K Manning, K Okonechnikov, M Block De, M Block De, M Choi, M Hauben, M Schmidt, Magdalena Woloszynska, Marc De Block, Martin Schmidt, MD Schultz, MG Murray, Michiel Van Bel, Mieke Van Lijsebettens, P Cubas, PF Gugger, PS Schnable, R Lister, RJ Schmitz, SE Jacobsen, SJ Cokus, T-F Hsieh, The Arabidopsis Genome Initiative, TJ Treangen, TP Gurp van, W Guo, X Cao, X Chen, X Li, X Wang, X Zhang, ZD Smith, ZL Liu   +60 more
core   +3 more sources

Characterization and Validation of Taagl66, a Gene Related to Fertility Conversion of Wheat in the Presence of Aegilops Kotschyi Cytoplasm

, 2023
Xianning Chen, Shengmei Tang, Xiaoran Gao, Fuqiang Niu, Xinyu Yang, Xiyue Song, Lingli Zhang   +6 more
openalex   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Cryptic MHC Polymorphism Revealed but Not Explained by Selection on the Class IIB Peptide-Binding Region [PDF]

, 2012
The immune genes of the major histocompatibility complex (MHC) are characterized by extraordinarily high levels of nucleotide and haplotype diversity. This variation is maintained by pathogen-mediated balancing selection that is operating on the peptide ...
Barcaccia, Barson, C. van Oosterhout, Castric, Cvitanich, Eimes, Ellegren, Fraser, Fraser, Fraser, Gibbs, Hughes, Hughes, Hughes, Hughes, Jensen, Kanagawa, Li, M. McMullan, Martin, Mehta, Mona, Nei, Piertney, Posada, Smith, Spurgin, Stone, Uyenoyama, Uyenoyama, V. Llaurens, van Oosterhout, Willing   +32 more
core   +1 more source

Conversion of steppe to cropland increases spatial heterogeneity of soil functional genes [PDF]

, 2023
Junjie Liu, Yaping Guo, Haidong Gu, Zhuxiu Liu, Xiaojing Hu, Zhenhua Yu, Yansheng Li, Lu‐Jun Li, Yueyu Sui, Jian Jin, Xiaobing Liu, Jonathan M. Adams, Guanghua Wang   +12 more
openalex   +1 more source

Gene conversion and purifying selection shape nucleotide variation in gibbon L/M opsin genes

BMC Evolutionary Biology, 2011
BackgroundRoutine trichromatic color vision is a characteristic feature of catarrhines (humans, apes and Old World monkeys). This is enabled by L and M opsin genes arrayed on the X chromosome and an autosomal S opsin gene.
Tomohide Hiwatashi, A. Mikami, T. Katsumura, B. Suryobroto, D. Perwitasari-Farajallah, S. Malaivijitnond, B. Siriaroonrat, Hiroki Oota, S. Goto, S. Kawamura   +9 more
semanticscholar   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

A droplet digital PCR assay to measure pilin antigenic variation frequency in Neisseria gonorrhoeae

mSphere
The strict human pathogen Neisseria gonorrhoeae (gonococcus [Gc]) infects an estimated 82 million individuals globally and is a World Health Organization-designated bacterial pathogen of public health importance due to escalating antimicrobial resistance.
Sarah J. Quillin, Di Luo, Aoife Gavagan, Arthur Prindle, H Steven Seifert   +4 more
doaj   +1 more source

Gene Conversion in Angiosperm Genomes with an Emphasis on Genes Duplicated by Polyploidization

Genes, 2011
Angiosperm genomes differ from those of mammals by extensive and recursive polyploidizations. The resulting gene duplication provides opportunities both for genetic innovation, and for concerted evolution. Though most genes may escape conversion by their
Xiyin Wang, A. Paterson
semanticscholar   +1 more source