Results 141 to 150 of about 925,042 (339)

Enhancer of terminal gene conversion, a New Mutation in Drosophila melanogaster That Induces Telomere Elongation by Gene Conversion [PDF]

, 2002
L. S. Melnikova, Pavel Georgiev
openalex   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Extensive Gene Conversion Drives the Concerted Evolution of Paralogous Copies of the SRY Gene in European Rabbits [PDF]

, 2010
Armando Geraldes, T. Rambo, Rod A. Wing, Nuno Ferrand, Michael W. Nachman   +4 more
openalex   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Meiotic Recombination in Drosophila Msh6 Mutants Yields Discontinuous Gene Conversion Tracts [PDF]

, 2007
Sarah J. Radford, Mathilde M. Sabourin, Susan McMahan, Jeff Sekelsky   +3 more
openalex   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

High homologous gene conservation despite extreme autopolyploid redundancy in sugarcane [PDF]

, 2011
Modern sugarcane (Saccharum spp.) has been recognized as one of the world's most efficient crops in solar energy conversion and as havlng the mast favorable input: output ratios. Beside ils importance for sugar production, ilthus became recently aprimary
Bocs, Stéphanie, Charron, Carine, D'Hont, Angélique, Droc, Gaëtan, Garsmeur, Olivier, Van Sluys, Marie-Anne   +5 more
core  

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Dynamics of a Human Interparalog Gene Conversion Hotspot [PDF]

, 2004
Elena Bosch, Matthew E. Hurles, Arcadi Navarro, Mark A. Jobling   +3 more
openalex   +1 more source

Conversion between 100-million-year-old duplicated genes contributes to rice subspecies divergence [PDF]

, 2020
Chendan Wei, Zhenyi Wang, Jianyu Wang, Jia Teng, Shaoqi Shen, Qimeng Xiao, Shoutong Bao, Yishan Feng, Yan Zhang, Yuxian Li, Sangrong Sun, Yuanshuai Yue, Chunyang Wu, Yanli Wang, Tianning Zhou, Wenbo Xu, Jigao Yu, Li Wang, Jinpeng Wang, Jinpeng Wang, Jinpeng Wang   +20 more
openalex   +1 more source