Results 151 to 160 of about 7,960,154 (346)
Molecular Oncology, EarlyView.The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Non‐thermal plasma treatment of melanoma cells induced epithelial‐mesenchymal transition (EMT) in a dose‐dependent fashion. This report highlights the critical need to further investigate potential adverse effects of non‐thermal plasma for cancer therapy and to optimize treatment parameters for clinical translation. Despite the promising results of non‐
Eline Biscop +10 more
wiley +1 more source
Evaluation of methods for detecting conversion events in gene clusters
BMC Bioinformatics, 2011 Background Gene clusters are genetically important, but their analysis poses significant computational challenges. One of the major reasons for these difficulties is gene conversion among the duplicated regions of the cluster, which can obscure their ...
Riemer Cathy +3 more
doaj +1 more source
GC-biased gene conversion drives accelerated evolution of ultraconserved elements in mammalian and avian genomes. [PDF]
Genome Res, 2023 Liu A +15 more
europepmc +1 more source
Molecular Oncology, EarlyView.Loss of primary cilia in endothelial cells promotes EndMT and vascular abnormalities in the ovarian tumor microenvironment through EphA2 activation. Using human samples, in vitro models, and endothelial‐specific Kif3a‐knockout mice, we show that primary cilia loss drives the acquisition of cancer‐associated fibroblast‐like phenotypes, thereby ...
Jin Gu Cho +11 more
wiley +1 more source
Diversification of immunoglobulin genes by gene conversion in the domestic chicken (Gallus gallus domesticus). [PDF]
Discov Immunol, 2023 Mallaby J +9 more
europepmc +1 more source
THE EVOLUTION OF MULTIGENE FAMILIES UNDER INTRACHROMOSOMAL GENE CONVERSION [PDF]
, 1984 Thomas Nagylaki
openalex +1 more source
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
Muller's ratchet of the Y chromosome with gene conversion. [PDF]
Genetics, 2022 Sakamoto T, Innan H.
europepmc +1 more source