Results 171 to 180 of about 8,864,769 (383)

Interlocus Gene Conversion, Natural Selection, and Paralog Homogenization. [PDF]

Mol Biol Evol, 2023
Yang Y, Xu T, Conant G, Kishino H, Thorne JL, Ji X.   +5 more
europepmc   +1 more source

The Processive Kinetics of Gene Conversion in Bacteria:Processivity of Gene Conversion [PDF]

, 2017
Gene conversion, non-reciprocal transfer from one homologous sequence to another, is a major force in evolutionary dynamics, promoting co-evolution in gene families, and maintaining similarities between repeated genes. However, the properties of the transfer – where it initiates, how far it proceeds, and how the resulting conversion tracts are affected
Johan, Paulsson, El Karoui, Meriem, Lindell, Monica, Hughes, Diarmaid   +3 more
openaire  

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Extensive Gene Conversion Drives the Concerted Evolution of Paralogous Copies of the SRY Gene in European Rabbits [PDF]

, 2010
Armando Geraldes, T. Rambo, Rod A. Wing, Nuno Ferrand, Michael W. Nachman   +4 more
openalex   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Codon usage bias in animals: disentangling the effects of natural selection, effective population size and GC-biased gene conversion

bioRxiv, 2017
N. Galtier, C. Roux, M. Rousselle, J. Romiguier, E. Figuet, S. Glémin, N. Bierne, L. Duret   +7 more
semanticscholar   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

NCOurd: modelling length distributions of NCO events and gene conversion tracts. [PDF]

Bioinformatics, 2023
Hardarson MT, Palsson G, Halldorsson BV.
europepmc   +1 more source

Characterization of a De Novo Conversion in Human Complement C4 Gene Producing a C4B5-Like Protein [PDF]

, 2002
Taina Jaatinen, Miia Eholuoto, Tarja Laitinen, Marja‐Liisa Lokki   +3 more
openalex   +1 more source