Results 181 to 190 of about 7,960,154 (346)

Chimeric diphtheria toxin–CCL8 cytotoxic peptide for breast cancer management

Molecular Oncology, EarlyView.
DTCCL8 is a recombinant fusion toxin that targets cancer cells expressing chemokine receptors. By combining diphtheria toxin with CCL8, DTCCL8 binds to multiple receptors on tumor cells and induces selective cytotoxicity. This strategy enables receptor‐mediated targeting of cancer and may support the development of chemokine‐guided therapeutics ...
Bernardo Chavez, Asieh Naderi, Kim‐Tuyen Huynh‐Dam, Vitali Sikirzhytski, Ioulia Chatzistamou, Hippokratis Kiaris   +5 more
wiley   +1 more source

Molecular analysis of human glycophorin MiIX gene shows a silent segment transfer and untemplated mutation resulting from gene conversion via sequence repeats [PDF]

, 1992
CH Huang, Flemming Skov, Geoff Daniels, Patricia Tippett, OO Blumenfeld   +4 more
openalex   +3 more sources

Gene Conversion amongst Alu SINE Elements. [PDF]

Genes (Basel), 2021
Doronina L, Reising O, Schmitz J.
europepmc   +1 more source

Spontaneous H-2 mutants provide evidence that a copy mechanism analogous to gene conversion generates polymorphism in the major histocompatibility complex.

, 1983
Larry R. Pease, Dan H. Schulze, Gertrude M. Pfaffenbach, S.G. Nathenson   +3 more
openalex   +1 more source

The interpretation of gene conversion data from ordered eight-spored asci [PDF]

, 1980
J. R. S. Fincham, William G. Hill, Eric Reeve   +2 more
openalex   +1 more source

ITGAV and SMAD4 influence the progression and clinical outcome of pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
In SMAD4‐positive pancreatic ductal adenocarcinoma (PDAC), integrin subunit alpha V (ITGAV) activates latent TGF‐β, which binds to the TGF‐β receptor and phosphorylates SMAD2/3. The activated SMAD2/3 forms a complex with SMAD4, and together they translocate to the nucleus, modulating gene expression to promote proliferation, migration, and invasion. In
Daniel K. C. Lee, Keyue Chen, Ryan Loke, Xiang Li, David Liubart, Golam T. Saffi, Jonathan T. S. Chow, Ché M. P. Melo, Lydia To, Leonardo Salmena   +9 more
wiley   +1 more source

Frequent somatic gene conversion as a mechanism for loss of heterozygosity in tumor suppressor genes. [PDF]

Genome Res, 2022
Takahashi KK, Innan H.
europepmc   +1 more source

INTRACHROMOSOMAL GENE CONVERSION AND THE MAINTENANCE OF SEQUENCE HOMOGENEITY AMONG REPEATED GENES

, 1982
Thomas Nagylaki, Thomas D. Petes
openalex   +2 more sources

Gene conversion-like mechanisms may generate polymorphism in human class I genes [PDF]

, 1987
G. Seemann, Reet Rein, Colin Brown, Hidde L. Ploegh   +3 more
openalex   +1 more source

Leveraging distant relatedness to quantify human mutation and gene conversion rates

bioRxiv, 2015
P. Palamara, L. Francioli, G. Genovese, Peter R. Wilton, A. Gusev, H. Finucane, S. Sankararaman, S. Sunyaev, P. D. de Bakker, J. Wakeley, I. Pe’er, A. Price   +11 more
semanticscholar   +1 more source