Results 181 to 190 of about 8,864,769 (383)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Evaluation of methods for detecting conversion events in gene clusters

BMC Bioinformatics, 2011
Background Gene clusters are genetically important, but their analysis poses significant computational challenges. One of the major reasons for these difficulties is gene conversion among the duplicated regions of the cluster, which can obscure their ...
Riemer Cathy, Hsu Chih-Hao, Song Giltae, Miller Webb   +3 more
doaj   +1 more source

Efficient repair of human genetic defect by CRISPR/Cas9-mediated interlocus gene conversion. [PDF]

Life Med, 2023
Yang F, Wang Y, Wang Q, Pang J, Liu G, Yang Y, Qin S, Zhang Y, Lai Y, Fu B, Zhu Y, Wang M, Kurita R, Nakamura Y, Liang D, Wu Y.   +15 more
europepmc   +1 more source

Recombination-dependent replication and gene conversion homogenize repeat sequences and diversify plastid genome structure.

American-Eurasian journal of botany, 2017
Tracey A Ruhlman, Jin Zhang, J. C. Blazier, J. Sabir, R. Jansen   +4 more
semanticscholar   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

somatic gene conversion

Citation: 'somatic gene conversion' in the IUPAC Compendium of Chemical Terminology, 5th ed.; International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.13688 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms ...
openaire   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Gene conversion homogenizes the CMT1A paralogous repeats.

, 2011
BACKGROUND: Non-allelic homologous recombination between paralogous repeats is increasingly being recognized as a major mechanism causing both pathogenic microdeletions and duplications, and structural polymorphism in the human genome.
Hurles, ME
core  

GC-biased gene conversion drives accelerated evolution of ultraconserved elements in mammalian and avian genomes. [PDF]

Genome Res, 2023
Liu A, Wang N, Xie G, Li Y, Yan X, Li X, Zhu Z, Li Z, Yang J, Meng F, Dou M, Chen W, Ma N, Jiang Y, Gao Y, Wang Y.   +15 more
europepmc   +1 more source

Estimating the parameters of background selection and selective sweeps in Drosophila in the presence of gene conversion

Proceedings of the National Academy of Sciences of the United States of America, 2017
J. Campos, Lei Zhao, B. Charlesworth
semanticscholar   +1 more source