Phenotype reversion as “natural gene therapy” in Fanconi anemia by a gene conversion event [PDF]
Frontiers in Genetics, 2023 Somatic mosaicism appears as a recurrent phenomenon among patients suffering from Fanconi anemia (FA), but its direct prognostic significance mostly remains an open question.
Ilaria Persico +8 more
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Gene conversion in human rearranged immunoglobulin genes [PDF]
Immunogenetics, 2006 Over the past 20 years, many DNA sequences have been published suggesting that all or part of the V<sub>H</sub> segment of a rearranged immunoglobulin gene may be replaced in vivo. Two different mechanisms appear to be operating. One of these
A Martin +40 more
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Characterization of Non-selected Intermolecular Gene Conversion in the Polyploid Haloarchaeon Haloferax volcanii [PDF]
Frontiers in Microbiology, 2021 Gene conversion is defined as the non-reciprocal transfer of genetic information from one site to a homologous, but not identical site of the genome. In prokaryotes, gene conversion can increase the variance of sequences, like in antigenic variation, but
Daniel Wasser +4 more
doaj +2 more sources
Gene conversion in the rice genome [PDF]
BMC Genomics, 2008 Background Gene conversion causes a non-reciprocal transfer of genetic information between similar sequences. Gene conversion can both homogenize genes and recruit point mutations thereby shaping the evolution of multigene families.
Vang Søren +7 more
doaj +10 more sources
Conversion events in gene clusters [PDF]
BMC Evolutionary Biology, 2011 Background Gene clusters containing multiple similar genomic regions in close proximity are of great interest for biomedical studies because of their associations with inherited diseases.
Hardison Ross C +9 more
doaj +4 more sources
Evolution of CCR5 and CCR2 Genes in Bats Showed Multiple Independent Gene Conversion Events [PDF]
Viruses, 2022 Chemokine receptors are an important determinant for the infectiousness of different pathogens, which are able to target the host cells by binding to the extracellular domains of these proteins.
Alexandre P. Fernandes +4 more
doaj +2 more sources
The Putative Endonuclease Activity of MutL Is Required for the Segmental Gene Conversion Events That Drive Antigenic Variation of the Lyme Disease Spirochete [PDF]
Frontiers in Microbiology, 2022 The Lyme disease spirochete Borrelia burgdorferi, encodes an elaborate antigenic variation system that promotes the ongoing variation of a major surface lipoprotein, VlsE.
Mildred Castellanos +4 more
doaj +2 more sources
A mechanism for gene conversion in fungi [PDF]
Genetical Research, 1964 A mechanism for gene conversion is proposed which overcomes many of the difficulties that any copy choice model encounters. It is suggested that along with general genetic pairing of homologous genomes at meiosis, effective pairing over short regions of the genetic material occurs at the molecular level by the separation of the strands of the DNA ...
Robin Holliday
openalex +3 more sources
Chromatin structure regulates gene conversion. [PDF]
PLoS Biology, 2007 Homology-directed repair is a powerful mechanism for maintaining and altering genomic structure. We asked how chromatin structure contributes to the use of homologous sequences as donors for repair using the chicken B cell line DT40 as a model.
W Jason Cummings +5 more
doaj +4 more sources
Widespread gene conversion in centromere cores. [PDF]
PLoS Biology, 2010 Centromeres are the most dynamic regions of the genome, yet they are typified by little or no crossing over, making it difficult to explain the origin of this diversity.
Jinghua Shi +5 more
doaj +6 more sources