Results 211 to 220 of about 8,864,769 (383)

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Gene Conversion amongst Alu SINE Elements. [PDF]

Genes (Basel), 2021
Doronina L, Reising O, Schmitz J.
europepmc   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Crossovers are associated with mutation and biased gene conversion at recombination hotspots

Proceedings of the National Academy of Sciences of the United States of America, 2015
Barbara Arbeithuber, A. Betancourt, T. Ebner, Irene Tiemann-Boege   +3 more
semanticscholar   +1 more source

Evolution of GC-biased gene conversion by natural selection. [PDF]

Genetics
Clessin A, Joseph J, Lartillot N.
europepmc   +1 more source

Frequent somatic gene conversion as a mechanism for loss of heterozygosity in tumor suppressor genes. [PDF]

Genome Res, 2022
Takahashi KK, Innan H.
europepmc   +1 more source

Targeted gene conversion induced by triplex-directed psoralen interstrand crosslinks in mammalian cells [PDF]

, 2009
Ying Liu, R. S. Nairn, Karen M. Vásquez
openalex   +1 more source

Skim-Based Genotyping by Sequencing Using a Double Haploid Population to Call SNPs, Infer Gene Conversions, and Improve Genome Assemblies

, 2022
Philipp E. Bayer
openalex   +2 more sources

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Modeling the length distribution of gene conversion tracts in humans from the UK Biobank sequence data. [PDF]

PLoS Genet
Masaki N, Browning SR.
europepmc   +1 more source