GC-biased gene conversion in X-chromosome palindromes conserved in human, chimpanzee, and rhesus macaque [PDF]
G3: Genes, Genomes, Genetics, 2021 Gene conversion is GC-biased across a wide range of taxa. Large palindromes on mammalian sex chromosomes undergo frequent gene conversion that maintains arm-to-arm sequence identity greater than 99%, which may increase their susceptibility to the effects
Emily K Jackson +3 more
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The Coalescent With Gene Conversion [PDF]
Genetics, 2000 Abstract In this article we develop a coalescent model with intralocus gene conversion. The distribution of the tract length is geometric in concordance with results published in the literature. We derive a simulation scheme and deduce a number of analytical results for this coalescent with gene conversion.
Wiuf, Carsten, Hein, J
openaire +5 more sources
Sexy gene conversions: locating gene conversions on the X-chromosome [PDF]
Nucleic Acids Research, 2009 Gene conversion can have a profound impact on both the short- and long-term evolution of genes and genomes. Here, we examined the gene families that are located on the X-chromosomes of human (Homo sapiens), chimpanzee (Pan troglodytes), mouse (Mus musculus) and rat (Rattus norvegicus) for evidence of gene conversion.
Liqing Zhang, Mark J. Lawson
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Omp2b Porin Alteration in the Course of Evolution of Brucella spp.
Frontiers in Microbiology, 2020 The genus Brucella comprises major pathogenic species causing disease in livestock and humans, e.g. B. melitensis. In the past few years, the genus has been significantly expanded by the discovery of phylogenetically more distant lineages comprising ...
Axel Cloeckaert +2 more
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The impact of mutation and gene conversion on the local diversification of antigen genes in African trypanosomes [PDF]
, 2012 Patterns of genetic diversity in parasite antigen gene families hold important information about their potential to generate antigenic variation within and between hosts.
Awadalla +12 more
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Evidence of extensive non-allelic gene conversion among LTR elements in the human genome [PDF]
, 2016 Long Terminal Repeats (LTRs) are nearly identical DNA sequences found at either end of Human Endogenous Retroviruses (HERVs). The high sequence similarity that exists among different LTRs suggests they could be substrate of ectopic gene conversion events.
CRUCIANI, Fulvio +4 more
core +1 more source
Down the Penrose stairs, or how selection for fewer recombination hotspots maintains their existence
eLife, 2023 In many species, meiotic recombination events tend to occur in narrow intervals of the genome, known as hotspots. In humans and mice, double strand break (DSB) hotspot locations are determined by the DNA-binding specificity of the zinc finger array of ...
Zachary Baker +2 more
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Frequent Recombination Events in Leishmania donovani: Mining Population Data
Pathogens, 2020 The Leishmania donovani species complex consists of all L. donovani and L. infantum strains mainly responsible for visceral leishmaniasis (VL). It was suggested that genome rearrangements in Leishmania spp.
Igor B. Rogozin +4 more
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Lack of RNA-DNA oligonucleotide (chimeraplast) mutagenic activity in mouse embryos [PDF]
, 2005 There are numerous reports of the use of RNA-DNA oligonucleoticles (chimeraplasts) to correct point mutations in vitro and in vivo, including the human apolipoprotein E gene (ApoE).
Owen, JS, Simons, JP, Tagalakis, AD
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Molecular Analysis of Spinal Muscular Atrophy: a genotyping protocol based on TaqMan® real-time PCR
Genetics and Molecular Biology, 2012 Spinal muscular atrophy (SMA) is an autosomal recessive inherited disorder caused by alterations in the survival motor neuron I (SMN1) gene. SMA patients are classified as type I-IV based on severity of symptoms and age of onset.
Fernanda Marques de Souza Godinho +3 more
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