Results 291 to 300 of about 925,042 (339)

Unraveling the Molecular Mechanisms of Glioma Recurrence: A Study Integrating Single‐Cell and Spatial Transcriptomics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Glioma recurrence severely impacts patient prognosis, with current treatments showing limited efficacy. Traditional methods struggle to analyze recurrence mechanisms due to challenges in assessing tumor heterogeneity, spatial dynamics, and gene networks.
Lei Qiu, Yinjiao Fei, Jiaxuan Ding, Kexin Shi, Jinyan Luo, Yuchen Zhu, Xingjian Sun, Gefei Jiang, Yuandong Cao, Weilin Xu, Shu Zhou   +10 more
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Immunoglobulin Gene Diversification by Gene Conversion

1993
Publisher Summary This chapter discusses recent advances in the study of gene conversion, primarily in the chicken, and on current models for the molecular mechanism of this form of somatic gene conversion. Most of the higher vertebrates, including teleost fish, the amphibian Xenopus, the reptile Caiman, and most of the mammalian species studied ...
W T, McCormack, L W, Tjoelker, C B, Thompson   +2 more
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Detecting gene conversion: primate visual pigment genes

Proceedings of the Royal Society of London. Series B: Biological Sciences, 1992
The effects of gene conversion can be detected in the DNA sequences of multigene families. We develop a permutation test of the significance of patterns of sequence mismatches, and apply it to the sequences of the red- and green-sensitive visual pigment genes of human and the diana monkey.
D J, Balding, R A, Nichols, D M, Hunt
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Priority in gene-conversion

Experientia, 1958
Die 1932 vonWinkler aufgestellte Hypothese der Genkonversion wurde bereits 1937 vonRenner und 1949 vonLindegren undMundkur bestatigt. Seit 1955 haben auch eine Reihe weiterer Autoren uber Befunde berichtet, welche operationsmassig nicht von dem vonWinkler beschriebenen Phanomen der Genkonversion zu unterscheiden sind, doch haben sie es ohne Ausnahme ...
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Intrachromosomal gene conversion in yeast

Nature, 1981
We have shown that the yeast Saccharomyces cerevisiae has a mechanism by which information from one gene can be transferred non-reciprocally to a repeated copy of the gene on the same chromosome. This intrachromosomal gene conversion may be important in maintaining sequence homogeneity within families of repeated eukaryotic genes.
H L, Klein, T D, Petes
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Conversion of ras Genes to Cancer Genes

1987
The cellular precursor of Harvey and Balb sarcoma virus, termed proto-ras, from certain tumors registers most frequently as an apparent cancer gene in the gene transfer assay with NIH 3T3 cells [1–4]. The viral ras gene is a dominant transforming gene that elicits all features of oncogenic transformation in a single step upon transfer into established ...
K, Cichutek, P H, Duesberg
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Gene Conversions May Obscure Actin Gene Family Relationships

Journal of Molecular Evolution, 2000
Phylogenetic hypotheses of muscle actin evolution are significantly different when a sea urchin is used as a representative echinoderm than when a sea star is used. While sea urchin muscle actins support an echinoderm-chordate sister relationship, sea star sequences suggest that echinoderm muscle actins are convergent with chordate muscle actins.
M E, White, B I, Crother
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Gene conversion among chemokine receptors

Gene, 2000
It has been proposed that proteins which are involved in host defence and susceptibility undergo accelerated evolution. Chemokine receptors have roles as pro-inflammatory agents acting in response to infection, and in addition are receptors for entry of viruses and other pathogens into cells. Consistent with this, their rate of evolution is higher than
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A Coalescence Approach to Gene Conversion

Theoretical Population Biology, 2000
In this paper we develop a coalescent model with intralocus gene conversion. Such models are of increasing importance in the analysis of intralocus variability and linkage disequilibrium. We derive the distribution of the waiting time until a gene conversion event occurs in a sample in terms of the distribution of the length of the transferred segment,
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Gene conversion models

Journal of Theoretical Biology, 1985
B S, Weir, T, Ohta, H, Tachida
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