Results 61 to 70 of about 7,960,154 (346)
eLife, 2017 In yeast, DNA breaks are usually repaired by homologous recombination (HR). An early step for HR pathways is formation of a heteroduplex, in which a single-strand from the broken DNA molecule pairs with a strand derived from an intact DNA molecule.
Yi Yin +3 more
doaj +1 more source
Estimation of Full-Length TprK Diversity in
mBio, 2020 Immune evasion and disease progression of Treponema pallidum subsp. pallidum are associated with sequence diversity in the hypervariable outer membrane protein TprK.
Amin Addetia +10 more
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Involvement of plastid, mitochondrial and nuclear genomes in plant-to-plant horizontal gene transfer
Acta Societatis Botanicorum Poloniae, 2014 This review focuses on plant-to-plant horizontal gene transfer (HGT) involving the three DNA-containing cellular compartments. It highlights the great incidence of HGT in the mitochondrial genome (mtDNA) of angiosperms, the increasing number of examples ...
Maria Virginia Sanchez-Puerta
doaj +1 more source
Evolutionary Stasis in Cycad Plastomes and the First Case of Plastome GC-Biased Gene Conversion
Genome Biology and Evolution, 2015 In angiosperms, gene conversion has been known to reduce the mutational load of plastid genomes (the plastomes). Particularly, more frequent gene conversions in inverted repeat (IR) than in single copy (SC) regions result in contrasting substitution ...
Chung-Shien Wu, S. Chaw
semanticscholar +1 more source
Gene Conversion in Human Genetic Disease [PDF]
Genes, 2010 Gene conversion is a specific type of homologous recombination that involves the unidirectional transfer of genetic material from a ‘donor’ sequence to a highly homologous ‘acceptor’. We have recently reviewed the molecular mechanisms underlying gene conversion, explored the key part that this process has played in fashioning extant human genes, and ...
Jian-Min Chen +2 more
openaire +2 more sources
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
Frontiers in MicrobiologyDouble-strand breaks (DSBs) are the most dangerous injuries for a genome. When unrepaired, death quickly ensues. In most bacterial systems, DSBs are repaired through homologous recombination. Nearly one-quarter of bacterial species harbor a second system,
Fares Osam Yáñez-Cuna +3 more
doaj +1 more source
GC-Content Evolution in Bacterial Genomes: The Biased Gene Conversion Hypothesis Expands
bioRxiv, 2014 The characterization of functional elements in genomes relies on the identification of the footprints of natural selection. In this quest, taking into account neutral evolutionary processes such as mutation and genetic drift is crucial because these ...
Florent Lassalle +5 more
semanticscholar +1 more source
Recombination and gene conversion
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 1992 Recombination is an important aspect of DNA metabolism. It leads to rearrangements of DNA sequences within genomes. Such genome rearrangements seem to be ubiquitous, since they play a role in evolution, human health and biotechnology. In medicine one important aspect of recombination is its role as one possible step in the multistep process of ...
openaire +2 more sources
Making tau amyloid models in vitro: a crucial and underestimated challenge
FEBS Letters, EarlyView.This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source