Results 81 to 90 of about 7,960,154 (346)
How homologous recombination generates a mutable genome
Human Genomics, 2005 Recombination and mutation have traditionally been regarded as independent evolutionary processes: the latter generates variation, which the former reshuffles.
Hurles Matthew
doaj +1 more source
PLoS Genetics, 2013 The male-specific region of the human Y chromosome (MSY) includes eight large inverted repeats (palindromes) in which arm-to-arm similarity exceeds 99.9%, due to gene conversion activity.
P. Hallast +4 more
semanticscholar +1 more source
Disruption of SETD3‐mediated histidine‐73 methylation by the BWCFF‐associated β‐actin G74S mutation
FEBS Letters, EarlyView.The β‐actin G74S mutation causes altered interaction of actin with SETD3, reducing histidine‐73 methylation efficiency and forming two distinct actin variants. The variable ratio of these variants across cell types and developmental stages contributes to tissue‐specific phenotypical changes. This imbalance may impair actin dynamics and mechanosensitive
Anja Marquardt +8 more
wiley +1 more source
Frontiers in ImmunologyPoultry immunoglobulin genes undergo diversification through homologous recombination (HR) and somatic hypermutation (SHM). Most animals share a similar system in immunoglobulin diversification, with the rare exception that human and murine ...
Hidetaka Seo +2 more
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Non-crossover gene conversions show strong GC bias and unexpected clustering in humans
eLife, 2015 Although the past decade has seen tremendous progress in our understanding of fine-scale recombination, little is known about non-crossover (NCO) gene conversion. We report the first genome-wide study of NCO events in humans. Using SNP array data from 98
Amy L Williams +13 more
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A strong deletion bias in nonallelic gene conversion. [PDF]
PLoS Genetics, 2012 Gene conversion is the unidirectional transfer of genetic information between orthologous (allelic) or paralogous (nonallelic) genomic segments. Though a number of studies have examined nucleotide replacements, little is known about length difference ...
Raquel Assis, Alexey S Kondrashov
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BRCA1 and CtIP suppress long tract gene conversion between sister chromatids
Nature Communications, 2013 BRCA1 controls early steps of the synthesis-dependent strand annealing (SDSA) pathway of homologous recombination, but has no known role following Rad51-mediated synapsis.
Gurushankar Chandramouly +5 more
semanticscholar +1 more source
Purification tags markedly affect self‐aggregation of CPEB3
FEBS Letters, EarlyView.Although recombinant proteins are used to study protein aggregation in vitro, uncleaved tags can interfere with accurate interpretation. Our findings demonstrate that His₆‐GFP and His₁₂ tags significantly affect liquid droplet and amyloid fibril formation in the intrinsically disordered region (IDR) of mouse cytoplasmic polyadenylation element‐binding ...
Harunobu Saito +6 more
wiley +1 more source
Long read sequencing reveals poxvirus evolution through rapid homogenization of gene arrays
eLife, 2018 Poxvirus adaptation can involve combinations of recombination-driven gene copy number variation and beneficial single nucleotide variants (SNVs) at the same loci.
Thomas A Sasani +3 more
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PLoS Genetics, 2013 Among the rare colonizers of heavy-metal rich toxic soils, Arabidopsis halleri is a compelling model extremophile, physiologically distinct from its sister species A. lyrata, and A. thaliana.
M. Hanikenne +6 more
semanticscholar +1 more source