Results 221 to 230 of about 3,728,322 (253)

Cas9/guide RNA-based gene-drive dynamics following introduction and introgression into diverse anopheline mosquito genetic backgrounds. [PDF]

BMC Genomics
Tushar T, Pham TB, Parker K, Crepeau M, Lanzaro GC, James AA, Carballar-Lejarazú R.   +6 more
europepmc   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Considerations for first field trials of low-threshold gene drive for malaria vector control. [PDF]

Malar J
Connolly JB, Burt A, Christophides G, Diabate A, Habtewold T, Hancock PA, James AA, Kayondo JK, Lwetoijera DW, Manjurano A, McKemey AR, Santos MR, Windbichler N, Randazzo F.   +13 more
europepmc   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Sequences within and upstream of the mouse Ets1 gene drive high level expression in B cells, but are not sufficient for consistent expression in T cells. [PDF]

PLoS One
Kearly A, Saelee P, Bard J, Sinha S, Satterthwaite A, Garrett-Sinha LA.   +5 more
europepmc   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Non-geographical population structure of malaria vector Anopheles gambiae and Anopheles coluzzii but weak structure in Anopheles arabiensis within Burkina Faso: Implications for vector control and gene drive implementation

Kaboré H, Brenas J, Kientega M, Traoré N, Pescod P, Sawadogo G, Koutoucheva AH, Lanfancotti A, Namountougou M, Maiga H, Nolan T, Miles A, Clarkson CS, Diabaté A.   +13 more
europepmc   +1 more source

Performance characteristics allow for confinement of a CRISPR toxin-antidote gene drive for population suppression in a reaction-diffusion model. [PDF]

Proc Biol Sci
Zhang S, Champer J.
europepmc   +1 more source

Talking About Gene Drive in Uganda: The Need for Science Communication to Underpin Engagement. [PDF]

Sci Commun
Hartley S, Stelmach A, Opesen C, Openjuru GL, Neema S.   +4 more
europepmc   +1 more source

Practical Application of a Relationship-Based Model to Engagement for Gene-Drive Vector Control Programs. [PDF]

Am J Trop Med Hyg
Kormos A, Nazaré L, Dos Santos AA, Lanzaro GC.   +3 more
europepmc   +1 more source