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Gene Duplication and Evolution
Science, 2001Lynch and Conery ([1][1]) presented one of the first serious efforts to study the evolutionary fate of gene duplication using genomic sequence data. Their analysis led to several interesting observations, particularly with respect to the rate of gene duplication in eukaryotic genomes and ...
Kevin R. Thornton, Manyuan Long
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Retention of duplicated genes in evolution
Trends in Genetics, 2022Gene duplication is a prevalent phenomenon across the tree of life. The processes that lead to the retention of duplicated genes are not well understood. Functional genomics approaches in model organisms, such as yeast, provide useful tools to test the mechanisms underlying retention with functional redundancy and divergence of duplicated genes ...
John S. Taylor +2 more
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, 2010 Due the sheer size and complexity of genomes, it is essential to develop automated methods to analyze them. To compare genomes, one distance measure that has been proposed is to determine the minimum number of evolutionary changes needed to transform one genome into another.
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Gene Duplication and Evolution
Science, 2002Abstract Motivated in part by Ohno’s (1970) influential book, substantial attention has been given to the idea that gene duplication is a major mechanism for the origin of new gene functions. A theoretical population genetic framework for understanding the evolutionary mechanisms responsible for the success versus demise of gene ...
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16 The evolution of gene duplicates
2002Gene and genome duplications have given rise to enormous variability among species in the number of genes within their genomes. Gene copies have in turn played important roles in adaptation, having been implicated in the evolution of the immune response, insecticide resistance, efficient protein synthesis, and vertebrate body plans. In this chapter, we
Paul J. Yong, Sarah P. Otto
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Current Opinion in Genetics & Development, 2001
Genomic sequencing projects have revealed the productivity of processes duplicating genes or entire chromosome segments. Substantial proportions of the yeast, Arabidopsis and human gene complements are made up of duplicates. This has prompted much interest in the processes of duplication, functional divergence and loss of genes, has renewed the debate ...
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Genomic sequencing projects have revealed the productivity of processes duplicating genes or entire chromosome segments. Substantial proportions of the yeast, Arabidopsis and human gene complements are made up of duplicates. This has prompted much interest in the processes of duplication, functional divergence and loss of genes, has renewed the debate ...
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Duplicated homeobox genes in Xenopus
Developmental Biology, 1989Multiple kinds of clones and restriction fragment polymorphisms are frequently encountered when analyzing genes of the tetraploid frog Xenopus laevis. Two types of cDNA clone have been isolated for homeobox gene 2. Analysis of their corresponding genomic clones confirmed the existence of clearly distinct restriction maps; in addition the nearby ...
Edward M. De Robertis +4 more
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Gene Duplication and Gene Loading
2014During the early evolution of life, gene duplication, the production of two copies of a DNA sequence, allowed the rapid diversification of enzymatically catalyzed reactions and an increase in genome size, providing also material for the invention of new enzymatic properties and complex regulatory and developmental patterns. A duplication may involve (i)
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Gene duplication in glutathione reductase
Journal of Molecular Biology, 1980Abstract The two nucleotide-binding domains of the flavo-enzyme glutathione reductase have similar chain folds. In order to evaluate whether the observed similarity is significant or not, a mean distance between both chains after best overlay was calculated. Insertions and deletions were taken into account. The significance of the observed similarity
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Detection of gene duplications and block duplications in eukaryotic genomes
Journal of Structural and Functional Genomics, 2003Several eukaryotic genomes have been completely sequenced and this provides an opportunity to investigate the extent and characteristics (e.g., single gene duplication, block duplication, etc.) of gene duplication in a genome. Detecting duplicate genes in a genome, however, is not a simple problem because of several complications such as domain ...
Andre R. O. Cavalcanti +4 more
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