Results 71 to 80 of about 199,466 (296)

Progressive Mauve: Multiple alignment of genomes with gene flux and rearrangement [PDF]

, 2009
Multiple genome alignment remains a challenging problem. Effects of recombination including rearrangement, segmental duplication, gain, and loss can create a mosaic pattern of homology even among closely related organisms.
Darling, Aaron E., Mau, Bob, Perna, Nicole T.   +2 more
core  

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Gene duplication and the origins of morphological complexity in pancrustacean eyes, a genomic approach

BMC Evolutionary Biology, 2010
Background Duplication and divergence of genes and genetic networks is hypothesized to be a major driver of the evolution of complexity and novel features.
Serb Jeanne M, Syme Anna E, Villacorta Carlos, Plachetzki David C, Pankey M Sabrina, Rivera Ajna S, Omilian Angela R, Oakley Todd H   +7 more
doaj   +1 more source

Gene duplication accelerates the pace of protein gain and loss from plant organelles [PDF]

Molecular Biology and Evolution, 2018
Introductory paragraphA hallmark of eukaryotic cells is the compartmentalisation of intracellular processes into specialised membrane-bound compartments known as organelles. Plant cells contain several such organelles including the nucleus, chloroplast, mitochondrion, peroxisome, golgi, endoplasmic reticulum and vacuole.
Costello, Rona, Emms, David M., Kelly, Steven   +2 more
openaire   +2 more sources

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Gene trees and species trees: irreconcilable differences

BMC Bioinformatics, 2012
Background Reconciliation is the classical method for inferring a duplication and loss history from a set of extant genes. It is based upon the notion of embedding the gene tree into the species tree, the incongruence between the two indicating evidence ...
Swenson Krister M, El-Mabrouk Nadia
doaj   +1 more source

Genome-wide signatures of adaptation to extreme environments in red algae

Nature Communications, 2023
Extremophilic red algae have thrived in hot springs for more than a billion years. Here, the authors analyze chromosome-level assemblies from three red algal species, finding that horizontal gene transfer, subtelomeric gene duplication, and loss of genes
Chung Hyun Cho, Seung In Park, Tzu-Yen Huang, Yongsung Lee, Claudia Ciniglia, Hari Chandana Yadavalli, Seong Wook Yang, Debashish Bhattacharya, Hwan Su Yoon   +8 more
doaj   +1 more source

Genome-scale phylogenetic analysis finds extensive gene transfer among Fungi [PDF]

, 2015
Although the role of lateral gene transfer is well recognized in the evolution of bacteria, it is generally assumed that it has had less influence among eukaryotes.
Boussau, Bastien, Daubin, Vincent, Davín, Adrián Arellano, Szöllősi, Gergely J., Tannier, Eric   +4 more
core   +4 more sources

Gene Duplications and Losses within the Cyclooxygenase Family of Teleosts and Other Chordates [PDF]

Molecular Biology and Evolution, 2008
Cyclooxygenase (COX) produces prostaglandins in animals via the oxidation and reduction of arachidonic acid. Different types and numbers of COX genes have been found in corals, sea squirts, fishes, and tetrapods, but no study has used a comparative phylogenetic approach to investigate the evolutionary history of this complex gene family.
Justin C, Havird, Michael M, Miyamoto, Keith P, Choe, David H, Evans   +3 more
openaire   +2 more sources