Results 161 to 170 of about 7,473,287 (361)
Molecular Oncology, EarlyView.TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach +8 more
wiley +1 more source
Genomic consequences of intensive inbreeding in miniature inbred pigs
BMC GenomicsBackground Inbreeding, a central theme in evolutionary and conservation biology, is a crucial practice in breeding to stabilize and enhance the specific traits or to establish inbred lines.
Hong-Man Chen +14 more
doaj +1 more source
RNAi: A Guide to Gene Silencing, edited by Gregory J. Hannon. 2003. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY. ISBN: 0-87969-641-9. [PDF]
, 2004 Joan A. Steitz
openalex +1 more source
EMT‐associated bias in the Parsortix® system observed with pancreatic cancer cell lines
Molecular Oncology, EarlyView.The Parsortix® system was tested for CTC enrichment using pancreatic cancer cell lines with different EMT phenotypes. Spike‐in experiments showed lower recovery of mesenchymal‐like cells. This was confirmed with an EMT‐inducible breast cancer cell line.
Nele Vandenbussche +8 more
wiley +1 more source
Stress-induced Apoptosis Associated with Null Mutation of ADAR1 RNA Editing Deaminase Gene [PDF]
, 2004 Qingde Wang +6 more
openalex +1 more source
Molecular Oncology, EarlyView.A DIA‐MS‐based proteomics analysis of serum samples from GB patients and healthy controls showed that high levels of IL1R2 and low levels of CRTAC1 and HRG in serum are associated with poor survival outcomes for GB patients. These circulating proteins could serve as biomarkers for the prediction of outcome in patients with GB.
Anne Clavreul +11 more
wiley +1 more source
Rapid evolution of RNA editing sites in a small non-essential plastid gene [PDF]
, 2004 Aretha Fiebig
openalex +1 more source
Molecular Oncology, EarlyView.Non‐small cell lung cancer targeted treatment is limited to a few known genetic alterations, with few alternatives in advanced treatment lines. To direct treatment decisions by drug sensitivity testing (DST), this study compared several methods for tumor cell isolation from malignant effusions, pointing to repeated CD45+ cell depletion for effective ...
Navit Mooshayef +10 more
wiley +1 more source
A versatile CRISPR/Cas9 system off-target prediction tool using language model
Communications BiologyGenome editing with the CRISPR/Cas9 system has revolutionized life and medical sciences, particularly in treating monogenic genetic diseases by enabling long-term therapeutic effects from a single intervention.
Weian Du +7 more
doaj +1 more source