Results 291 to 300 of about 15,770,266 (354)
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Long-range enhancer–promoter contacts in gene expression control
Nature Reviews Genetics, 2019Stefan Schoenfelder, Peter Fraser
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Clinical Orthopaedics and Related Research, 2000
Gene therapy is the process whereby a therapeutic protein is synthesized from a DNA molecule (gene) that has been inserted into the cells. The goal is to produce the desired protein in the proper quantity in the proper location. Successful designing of vectors for gene therapy requires knowledge of gene structure and regulation.
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Gene therapy is the process whereby a therapeutic protein is synthesized from a DNA molecule (gene) that has been inserted into the cells. The goal is to produce the desired protein in the proper quantity in the proper location. Successful designing of vectors for gene therapy requires knowledge of gene structure and regulation.
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Nephron Experimental Nephrology, 2006
Genome-wide sequencing and increasing use of microarrays has resulted in the identification of a large number of new genes which may have important functional roles in development and onset of disease. Classical approaches in gene expression studies fall short in providing information about cellular localization of these genes and their relative levels
Rajesh, Kher, Robert L, Bacallao
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Genome-wide sequencing and increasing use of microarrays has resulted in the identification of a large number of new genes which may have important functional roles in development and onset of disease. Classical approaches in gene expression studies fall short in providing information about cellular localization of these genes and their relative levels
Rajesh, Kher, Robert L, Bacallao
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Annual Review of Genetics, 1970
A hormone is an effector molecule produced in low concentration by one cell which evokes a physiological response in another. In vertebrates, nu merous classes of chemically unrelated compounds such as polypeptides, amino acids, amines, fatty acid derivatives, and steroids have hormonal activity. Certain of these substances probably are themselves the
G M, Tomkins, D W, Martin
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A hormone is an effector molecule produced in low concentration by one cell which evokes a physiological response in another. In vertebrates, nu merous classes of chemically unrelated compounds such as polypeptides, amino acids, amines, fatty acid derivatives, and steroids have hormonal activity. Certain of these substances probably are themselves the
G M, Tomkins, D W, Martin
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On the Expression of a Structural Gene
Journal of Molecular Biology, 1960Experiments were made on the kinetics of β-galactosidase production by zygotes formed upon mating of inducible, lac+(Hfr z+i+), and constitutive, lac−(F−z−i−), strains of Escherichia coli K12. Enzyme formation commenced within two minutes of the time of injection of the z+ gene.
Monica Riley +3 more
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American Journal of Respiratory Cell and Molecular Biology, 1989
Abstract Collagens are extracellular matix proteins that play important structural roles in many tissues and organs. Thirteen types of collagen, the products of 23 genes, have been described. Most of the collagen genes are developmentally regulated; a given tissue or cell type expresses only a subset of the collagen genes.
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Abstract Collagens are extracellular matix proteins that play important structural roles in many tissues and organs. Thirteen types of collagen, the products of 23 genes, have been described. Most of the collagen genes are developmentally regulated; a given tissue or cell type expresses only a subset of the collagen genes.
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1999
Altering the expression of genes has become a rapidly evolving area of research in medicine. The realization that gene expression is important in a wide range of diseases, and not just in inherited disease, has resulted in recognition of the whole fi eld of gene expression as one that may bring new therapeutic options.
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Altering the expression of genes has become a rapidly evolving area of research in medicine. The realization that gene expression is important in a wide range of diseases, and not just in inherited disease, has resulted in recognition of the whole fi eld of gene expression as one that may bring new therapeutic options.
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Nature Structural & Molecular Biology, 2004
Gene expression is a highly interconnected multistep process. A recent meeting in Iguazu Falls, Argentina, highlighted the need to uncover both the molecular details of each single step as well as the mechanisms of coordination among processes in order to fully understand the expression of genes.
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Gene expression is a highly interconnected multistep process. A recent meeting in Iguazu Falls, Argentina, highlighted the need to uncover both the molecular details of each single step as well as the mechanisms of coordination among processes in order to fully understand the expression of genes.
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New England Journal of Medicine, 1994
Genetics is a language with rules of composition that give the tissues of the body their special traits. These rules govern the activation of particular subgroups of genes, which determine not only the unique characteristics of a cell type but also whether it remains quiescent, divides, or dies. The timing of gene activation is very important. If genes
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Genetics is a language with rules of composition that give the tissues of the body their special traits. These rules govern the activation of particular subgroups of genes, which determine not only the unique characteristics of a cell type but also whether it remains quiescent, divides, or dies. The timing of gene activation is very important. If genes
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Expression of the Fibronectin Gene
American Journal of Respiratory Cell and Molecular Biology, 1989Abstract Fibronectin (FN) is an extracellular matrix protein that acts as a substrate for cell migration and adhesion during development. FN adheres to cells through a dimeric membrane protein, the FN receptor. Antibodies to FN and synthetic peptides that inhibit FN-receptor interaction inhibit gastrulation, block neural crest cell ...
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