Results 321 to 330 of about 7,252,476 (351)

Screening the partial coding region of metallothionein isoform-2 gene in Zebu cattle.

, 2016
Pranjal Gholap, D. S. Kale, Kannan Krishnamurthi, A. R. Sirothia, M. D. Kothekar   +4 more
openalex   +1 more source

Microcystin‐LR Triggers Renal Tubular Ferroptosis Through Epigenetic Repression of GPX4: Implications for Environmental Nephrotoxicity

Advanced Science, EarlyView.
MC‐LR stabilizes DNMT1/3a by blocking their ubiquitin‐mediated degradation, leading to Gpx4 promoter hypermethylation and E2F4/NCoR‐associated transcriptional repression, which drives renal tubular ferroptosis in mice. Pharmacological inhibition of DNA methylation (SGI‐1027) or ferroptosis (Fer‐1) disrupts this DNMT‐GPX4 axis, thereby alleviating MC‐LR‐
Shaoru Zhang, Qi Gao, Yi Peng, Huan Zhang, Qi Shen, Meihong Guo, Yuqing Gong, Lei Chu, Weidong Wu, Yanting Wen, Wangsen Cao, Yong Wang, Lihui Wang   +12 more
wiley   +1 more source

Functional Characterization of <i>HGD</i> Gene Variants by Minigene Splicing Assay. [PDF]

Int J Mol Sci
Nekrasov A, Shchukina E, Rimskaya B, Zakharova E.   +3 more
europepmc   +1 more source

Spatial Transcriptomics and snRNA‐seq Expose CAF Niches Orchestrating Dual Stromal‐Immune Barriers in Hepatocellular Carcinoma

Advanced Science, EarlyView.
HmmyCAFs may form a triple immunosuppressive niche: possibly secrete ECM (POSTN, etc.) as physical barriers to block CD8⁺ T cells, induce CD8⁺ T exhaustion via those molecules, and use HIF‐1α‐driven metabolism to create acidic, nutrient‐poor microenvironments that suppress T cells.
Yingxue Li, Changxiang Huan, Haoting Sun, Wei Zhang, Zhen Guo, Chuanyu Li, Jia Yao, Zhiqi Zhang, Shizhe Yu, Qiongzhu Dong, Lunxiu Qin, Jinze Li, Lianqun Zhou   +12 more
wiley   +1 more source

Isoform-level analyses of 6 cancers uncover extensive genetic risk mechanisms undetected at the gene-level. [PDF]

Br J Cancer
Chang YH, Bresnahan ST, Taylor Head S, Harrison TA, Yu Y, Huff CD, Pasaniuc B, Lindström S, Bhattacharya A.   +8 more
europepmc   +1 more source

FGFR2-IIIc isoform detection reveals prognostic prevalence and a functional link to mesenchymal transition in gastric and gastroesophageal junction cancer. [PDF]

ESMO Open
Hashimoto T, Iida N, Kadowaki S, Makiyama A, Machida N, Takahashi N, Boku S, Kudo T, Oki E, Ohtsubo K, Kawakami T, Okano N, Komatsu Y, Yuki S, Sakamoto N, Kuwata T, Yamashita R, Amisaki M, Shibuki T, Imai M, Fujisawa T, Nakamura Y, Bando H, Shitara K, Yoshino T.   +24 more
europepmc   +1 more source

Systematic characterization of full-length RNA isoforms in human colorectal cancer at single-cell resolution. [PDF]

Protein Cell
Lu P, Zhang Y, Cui Y, Liao Y, Liu Z, Cao ZJ, Liu JE, Wen L, Zhou X, Fu W, Tang F.   +10 more
europepmc   +1 more source

Protein phosphatase 2A (PP2A) function in male germ cells and its importance for male fertility. [PDF]

Endocr Connect
Simon V.
europepmc   +1 more source

mRNA Isoforms and Variants in Health and Disease. [PDF]

Int J Mol Sci
Shila S, Dahiya V, Hisle C, Bahadursingh E, Thiyagarajan R, Fields PE, Rumi MAK.   +6 more
europepmc   +1 more source

The p48 isoform of the PA2G4/EBP1/ITAF45 oncoprotein is required for the encephalomyocarditis virus IRES-driven translation initiation. [PDF]

Nucleic Acids Res
Kushchenko AS, Golovko VA, Panova EA, Sukhinina AP, Gladneva EE, Krasota AY, Ivin YY, Poteryakhina AV, Agol VI, Dmitriev SE.   +9 more
europepmc   +1 more source