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Automating the construction of gene ontologies
Nature Biotechnology, 2013Manual curation of biological ontologies is recapitulated by an algorithmic approach, supplementing the Gene Ontology and enabling the discovery of relationships among genes and proteins.
Kara, Dolinski, David, Botstein
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The ontology of the gene ontology.
AMIA ... Annual Symposium proceedings. AMIA Symposium, 2004The rapidly increasing wealth of genomic data has driven the development of tools to assist in the task of representing and processing information about genes, their products and their functions. One of the most important of these tools is the Gene Ontology (GO), which is being developed in tandem with work on a variety of bioinformatics databases.
Barry Smith 0001 +2 more
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Is Wikipedia a Latent Gene Ontology?
2017 IEEE 26th International Conference on Enabling Technologies: Infrastructure for Collaborative Enterprises (WETICE), 2017Despite the significant contribution from specialized ontologies and text mining methods, the evaluation of the semantic similarity of genes remains difficult because of the complex functions in which genes are involved. A less exploited resource is Wikipedia that stores more than 10400 articles about human genes: each gene name identifies the ...
Dessì€, Nicoletta, Atzori, Maurizio
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A short study on the success of the Gene Ontology
Web Semantics, 2004While most ontologies have been used only by the groups who created them and for their initially defined purposes, the Gene Ontology (GO), an evolving structured controlled vocabulary of nearly 16,000 terms in the domain of biological functionality, has been widely used for annotation of biological-database entries and in biomedical research.
Michael Bada +2 more
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Methods for Gene Ontology Annotation
2007The Gene Ontology (GO) is an established dynamic and structured vocabulary that has been successfully used in gene and protein annotation. Designed by biologists to improve data integration, GO attempts to replace the multiple nomenclatures used by specialised and large biological knowledgebases.
Emily, Dimmer +3 more
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Integrating Ontological Information about Genes
2014 IEEE 23rd International WETICE Conference, 2014With the advent of biological ontologies an increasing amount of methods are emerging for enriching gene information by means of their annotations. However, problems occur in assessing semantic similarity over genetic aspects that are represented independently in different schemas when, in reality, they are not.
DESSI, NICOLETTA +2 more
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Gene Regulatory Networks from Gene Ontology
2013Gene Ontology (GO) provides a controlled vocabulary and hierarchy of terms to facilitate the annotation of gene functions and molecular attributes. Given a set of genes, a Gene Ontology Network (GON) can be constructed from the corresponding GO annotations and semantic relations among GO terms.
Wenting Liu +5 more
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Gene multifunctionality scoring using gene ontology
Journal of Bioinformatics and Computational Biology, 2018Multifunctional genes are important genes because of their essential roles in human cells. Studying and analyzing multifunctional genes can help understand disease mechanisms and drug discovery. We propose a computational method for scoring gene multifunctionality based on functional annotations of the target gene from the Gene Ontology. The method is
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On ontologies for biologists: the Gene Ontology--untangling the web.
Novartis Foundation symposium, 2003The mantra of the 'post-genomic' era is 'gene function'. Yet surprisingly little attention has been given to how functional and other information concerning genes is to be captured, made accessible to biologists or structured in a computable form. The aim of the Gene Ontology (GO) Consortium is to provide a framework for both the description and the ...
Michael, Ashburner, Suzanna, Lewis
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Sequence Ontology terminology for gene regulation
Biochimica Et Biophysica Acta - Gene Regulatory Mechanisms, 2021David Sant +2 more
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