Results 221 to 230 of about 360,906 (263)

Selector Genes, Polymorphisms, and Evolution

Science, 1996
Evolution has been thought to act on small changes in the characteristics of organisms coded by genes called realizator genes. D. Tautz explains how a new result in this issue of Science by Gibson and Hogness ( p. 200 ) shows that this may not always be true. A small phenotypic variation in
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Polymorphism of the human MUC genes

Frontiers in Bioscience, 2001
Mucins encoded by the MUC genes share the common feature of having an extensive tandem repeat region that encompasses a large proportion of the coding sequence. In many of the genes this tandem repeat region shows a great deal of allelic length variation and recently studies have demonstrated person to person variation in pattern of nucleotide or amino-
J, Fowler, L, Vinall, D, Swallow
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Polymorphism of the Pa Gene

American Journal of Reproductive Immunology, 1992
PROBLEM: This study was undertaken to identify the number of alleles of the Pa gene at the DNA level and to correlate the presence of the different alleles with the ability of a strain to elicit an anti‐Pa antibody response when mated with a WF female. The Pa gene is present in both Pa + and Pa − strains of rats, but it has unique restriction fragment ...
A G, Vishteh, H W, Kunz, A L, Cortese Hassett, T J, Gill   +3 more
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Gene polymorphisms in childhood ALL

Pediatric Blood & Cancer, 2009
AbstractAcute lymphoblastic leukemia (ALL) is the most common malignancy diagnosed in children. Inherited predisposition and exposure to exogenous leukemogenic agents have been investigated as potential risk factors. Current therapy results in 5‐year event‐free survival exceeding 80% in children in developed countries.
Nikolaos V, Karathanasis, Despoina M, Choumerianou, Maria, Kalmanti   +2 more
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A new polymorphism in the gene for GAP43

Human Genetics, 1993
A new polymorphism has been identified in the 3'-untranslated region of the gene for GAP43. It is present with a frequency of 0.327 in the Centre d'Etude du Polymorphisme Humaine (CEPH) parents and is slightly lower in Alzheimer's (0.269) and Parkinson's (0.231) patients.
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Cytokine gene polymorphisms in psoriasis

British Journal of Dermatology, 2001
Cytokine production is under genetic control, and certain allelic variants of cytokine genes are associated with higher or lower cytokine production in vitro and in vivo. Psoriasis is associated with an overexpression in the involved skin of T-helper cell type 1 (Th1) cytokines, e.g.
Craven, N. M., Jackson, C. W., Kirby, B., Perrey, C., Pravica, V., Hutchinson, I. V., Griffiths, C. E M   +6 more
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Polymorphism of FCGR3A gene in sarcoidosis

Human Immunology, 2014
We showed increased level of immune complexes (ICs) with mycobacterial heat shock proteins (Mtb-hsp) and increased expression of receptors for Fc fragment of immunoglobulin G (FcγR) I-III on blood monocytes with their increased phagocytic activity, responsible for clearance of these ICs in sarcoidosis (SA).
Marlena J. Typiak, Krzysztof Rębała, Maria Dudziak, Anna Dubaniewicz   +3 more
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The elucidation of KIR2DL4 gene polymorphism

Molecular Immunology, 2008
The killer cell immunoglobulin-like receptors (KIRs) on NK cells recognize defined groups of HLA class I alleles. By this mechanism the NK cells fulfil a significant role in the first line of defense against infectious agents and cancer. For the treatment of leukaemia this NK cell allorecognition is of great importance.
Jennifer, Schellekens, Marcel G J, Tilanus, Erik H, Rozemuller   +2 more
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Polymorphism in the RD (D6S45) gene

Human Genetics, 1992
The RD (D6S45) gene in the class III region of the HLA major histocompatibility complex encodes a protein normally containing 24 consecutive basic-acidic dipeptide repeats. We determined the frequency of variations in the number of repeats by use of the polymerase chain reaction. Of 107 subjects 7 (3.3%) carried genes encoding 22 or 23 repeats.
P C, White, J, Vitek, R G, Lahita, P W, Speiser   +3 more
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The polymorphism of the complement genes in HLA

Annales de l'Institut Pasteur / Immunologie, 1985
Genes coding for the complement proteins C2, C4A, C4B and factor B lie between HLA-D and HLA-B in HLA, the major histocompatibility complex in man. All the complement components are polymorphic, particularly C4, which has many alleles at each locus. The genetic complexity of C4 extends to the number of loci each of which may be deleted or duplicated on
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