Results 131 to 140 of about 758,578 (355)

Integrated Transcriptomics Reveals Evolutionary Trajectories and Cell Density‐Dependent Mechanisms in Aldosterone‐Producing Adenomas

Advanced Science, EarlyView.
Aldosterone‐producing adenomas (APAs) develop via two distinct paths: directly from adrenal zona glomerulosa (zG) cells, or stepwise from zG cells through aldosterone‐producing micronodules (APMs) before progressing to APAs. Advanced single‐cell and spatial analyses identified distinct cell states linked to oxidative stress and cell–cell interactions ...
Zhuolun Sun, Changying Jing, Martina Tetti, Siyuan Gong, Jia Wei, Yingxian Pang, Martin Reincke, Tracy Ann Williams   +7 more
wiley   +1 more source

Polymorphism of the DNA repair genes RAD51 and XRCC2 in smoking- and drinking-related laryngeal cancer in a Polish population [PDF]

, 2012
Hanna Romanowicz‐Makowska, Beata Smolarz, Marzena Gajęcka, Katarzyna Kiwerska, Małgorzata Rydzanicz, Dariusz Kaczmarczyk, Jurek Olszewski, Krzysztof Szyfter, Janusz Błasiak, Alina Morawiec-Sztandera   +9 more
openalex   +1 more source

A Patient‐Derived Organ‐on‐Chip Platform for Modeling the Tumor Microenvironment and Drug Responses in Pancreatic Cancer

Advanced Science, EarlyView.
Researchers have developed a patient‐derived organ‐on‐a‐chip model for pancreatic cancer by integrating cancer cells with supportive stromal and immune cells inside a microfluidic device. This system mimics the tumor microenvironment, enabling personalized testing of chemotherapy and immunotherapy, and offering new insights into how targeting ...
Darbaz Adnan, Natan Roberto de Barros, Luca S. Santovito, Xuhong Cheng, Kristi M. Lawrence, Mariah K. Barnett, Martine D. Boetto, Neal Mehta, Ajaypal Singh, Lin Cheng, Xiangsheng Huang, Faraz Bishehsari   +11 more
wiley   +1 more source

Genomics Insights Into High‐Latitude Adaptation of Tibetan Macaques

Advanced Science, EarlyView.
Tibetan macaques exhibit unique adaptations to cold, high‐latitude environments, including shortened tails and enhanced fat storage. Genomic analyses reveal a species‐specific TBX6 mutation linked to tail reduction and selection on lipid metabolism genes.
Rusong Zhang, Ying Hu, Yang Teng, Jiwei Qi, Yangzhen Ciren, Lin Zhang, Qiao Du, Wencai Xu, Liang Zhou, Zhenxin Fan, Jinchuan Xing, Ming Li, Jing Li   +12 more
wiley   +1 more source

Dependence of Aerobic Performance of Athletes on Polymorphism of Genes

Central European Journal of Sport Sciences and Medicine, 2015
The adaptation of an athlete to systematic physical exercise has been shown to be determined by a combination of great many genes. The aim of our study was to investigate the dependence of the aerobic capacity parameters in sport on the set of gene ...
Victor E. Dosenko, Svitlana B. Drozdovska, Vladimir N. Ilyin, Olena M. Lysenko   +3 more
doaj  

Genes of the serotonergic and dopaminergic pathways and their interaction affect the expression of Behavioural and Psychological Symptoms in Dementia (BPSD). [PDF]

, 2009
Although there is evidence for the involvement of genes of serotonergic and dopaminergic systems in the manifestation of the Behavioural and Psychological Symptoms in Dementia (BPSD), genetic association studies are contradictory.
Belinda Martin, Brian Lawlord, Gillian Hamilton, John Powell, Julie Williams, Michael Gill, Michael J. Owen, Michelle Lupton, Nicola Archer, Paul hollingworth, Petroula Proitsi, Simon Lovestone, Suzanne Reeves   +12 more
core   +1 more source

Polymorphisms in ABCB1 and CYP19A1 genes affect anastrozole plasma concentrations and clinical outcomes in postmenopausal breast cancer patients [PDF]

, 2016
Guillermo Gervasini, Carlos Jara, C Olier, Nuria Romero-Laorden, Ruth Martínez, Juan Antonio Carrillo   +5 more
openalex   +1 more source

Association analysis of polymorphisms of candidate genes for laying traits in Yangzhou geese

, 2023
Yang Zhang, Laidi Wang, Jijie Li, Qiang Bao, Yong Zhang, Guobin Chang, Guohong Chen   +6 more
openalex   +1 more source

Domestication of Tartary Buckwheat Shaped a Regulatory Module for Seedling Salt Tolerance by Targeting the Magnesium Transporter Gene FtMGT2

Advanced Science, EarlyView.
Domestication of Tartary buckwheat is selected for a salt tolerance mechanism involving the magnesium transporter FtMGT2. Its expression is controlled by the FtAGL16‐FtMYB15L module, which is stabilized under salt stress through a competitive interaction that blocks its degradation by the E3 ligase FtBRG1, ultimately boosting Na⁺ efflux and plant ...
Xiang Lu, Yuqi He, Wenfeng Weng, Zebin Liu, Yuanfen Gao, Yaliang Shi, Wei Li, Dili Lai, Mengyu Zhao, Rintu Jha, Hui Zhao, Guangsheng Li, Chaonan Guan, Shuai Shao, Jingjun Ruan, Sun Hee Woo, Yinan Ouyang, Muriel Quinet, Milen I. Georgiev, Alisdair R. Fernie, Congcong Hou, Kaixuan Zhang, Xu Liu, Meiliang Zhou   +23 more
wiley   +1 more source

Association of Serum Biomarkers with C-X-C Motif Chemokine Receptor 3 Gene Polymorphism and Severity of Coronavirus-2019 Infection

Biomedical and Biotechnology Research Journal
Background: Polymorphisms in the C-X-C motif chemokine receptor 3 (CXCR3) gene may impact the immune system’s reaction to infections such as coronavirus disease-19 (COVID-19).
Usha Sachidananda Adiga, Sachidananda Narasimha Adiga, Tirthal Rathnakar Rai   +2 more
doaj   +1 more source