Results 151 to 160 of about 396,263 (266)

Expanding Chemical Space of Nucleic Acid Nanoparticles for Tunable Antiviral‐Like Immunomodulatory Responses and Potent Adjuvant Activity

Advanced Functional Materials, EarlyView.
We introduce a nucleic acid nanoparticle (NANP) platform designed to be rrecognized by the human innate immune system in a regulated manner. By changing chemical composition while maintaining constant architectural parameters, we identify key determinants of immunorecognition enabling the rational design of NANPs with tunable immune activation profiles
Martin Panigaj, Hannah S. Newton, Jian Wang, Laxmi Pandey, Yelixza I. Avilla, Phong Nguyen, Morgan Chandler, Justin Halman, Yasmine Radwan, Stephanie Smith, Elijah Edmondson, Simone Difilippantonio, Chelsea Sanders, Bao Tran, Yongmei Zhao, Shaojun Xie, Edward Cedrone, Barry W. Neun, Meni Wanunu, Nikolay V. Dokholyan, Marina A. Dobrovolskaia, Kirill A. Afonin   +21 more
wiley   +1 more source

Gene pool preservation across time and space In Mongolian-speaking Oirats. [PDF]

Eur J Hum Genet
Balinova N, Hudjašov G, Pankratov V, Pennarun E, Reidla M, Metspalu E, Batyrov V, Khomyakova I, Reisberg T, Parik J, Dzhaubermezov M, Aiyzhy E, Balinova A, El'chinova G, Spitsyna N, Khusnutdinova E, Metspalu M, Tambets K, Villems R, Kushniarevich A.   +19 more
europepmc   +1 more source

Diversity Assessment of the Montenegrin Maize Landrace Gene Pool Maintained in Two Gene Banks. [PDF]

Plants (Basel), 2021
Babić V, Andjelkovic V, Jovovic Z, Babic M, Vasic V, Kravic N.   +5 more
europepmc   +1 more source

A Vascular Microphysiological Model of Lung Fibrosis Reveals That Myofibroblasts and IPF Patient‐Derived Fibroblasts Impair Angiogenesis and Vasculogenesis

Advanced Functional Materials, EarlyView.
A microphysiological lung fibrosis model recapitulates myofibroblast–vascular interactions. Induced myofibroblasts and patient‐derived IPF fibroblasts impair angiogenesis and increase vascular permeability via TGF‐β1–driven signaling. Pharmacological interventions with SB 431542 and VEGF supplementation restore vascular morphology and barrier function.
Elena Cambria, Adriana Blazeski, Eunkyung Clare Ko, Tran Thai, Shania Dantes, David A. Barbie, Sarah E. Shelton, Roger D. Kamm   +7 more
wiley   +1 more source

Reconstructing the ancestral gene pool to uncover the origins and genetic links of Hmong-Mien speakers. [PDF]

BMC Biol
Gao Y, Zhang X, Chen H, Lu Y, Ma S, Yang Y, Zhang M, Xu S.   +7 more
europepmc   +1 more source

Filaggrin Gene Mutation in Pediatric Patients with Atopic Dermatitis: A Look into Indian Gene Pool, a Pilot Study.

Indian J Dermatol, 2023
Rajeshwari KA, Thomas MM, Nagaraj G.
europepmc   +1 more source

Drought Stress Triggers Shifts in the Root Microbial Community and Alters Functional Categories in the Microbial Gene Pool. [PDF]

Front Microbiol, 2021
Xie J, Dawwam GE, Sehim AE, Li X, Wu J, Chen S, Zhang D.   +6 more
europepmc   +1 more source

Generating Cell Surface Nucleated Hydrogels with an Artificial Membrane‐Binding Transglutaminase

Advanced Functional Materials, EarlyView.
Cell‐based therapies require advanced strategies to enhance cell delivery and bioactivity. Cell membrane engineering offers an avenue to impart new functions to delivered cells to boost their viability and function. Here, an artificial membrane‐binding transglutaminase is generated and biophysically characterized.
Rosalia Cuahtecontzi Delint, Tao Li, Kapil D. Patel, Will H. Zhang, Ben M. Carter, Graham J. Day, Adam W. Perriman   +6 more
wiley   +1 more source

Demographic fluctuations in bloodstream Staphylococcus aureus lineages configure the mobile gene pool and antimicrobial resistance. [PDF]

NPJ Antimicrob Resist
Souza SSR, Smith JT, Marcovici MM, Eckhardt EM, Hansel NB, Martin IW, Andam CP.   +6 more
europepmc   +1 more source

Structural variants in the barley gene pool: precision and sensitivity to detect them using short-read sequencing and their association with gene expression and phenotypic variation. [PDF]

Theor Appl Genet, 2022
Weisweiler M, Arlt C, Wu PY, Van Inghelandt D, Hartwig T, Stich B.   +5 more
europepmc   +1 more source