Results 131 to 140 of about 5,314,306 (291)

Sequences within the gag gene of mouse mammary tumor virus needed for mammary gland cell transformation.

, 2006
Previously, we identified a group of replication-competent exogenous mouse mammary tumor viruses that failed to induce mammary tumors in susceptible mice. Sequence comparison of tumorigenic and tumor-attenuated virus variants has linked the ability of
Brooke A. Jude, Ingrid Swanson, Tatyana V. Golovkina, Jude, B A, Zachary E. Smith, Golovkina, T V, Andrew Pucker, Pucker, A, Smith, Z E, Swanson, I, Zhang, A R, Annie R. Zhang   +11 more
core   +1 more source

Sickle Cell Disease: Historical Overview and Current Therapies

Prenatal Diagnosis, EarlyView.
ABSTRACT Sickle cell disease (SCD) affects millions worldwide, yet the limited treatment options currently available do not always adequately control the disease and carry significant side effects. At present, the only curative treatment is hematopoietic stem cell (HSC) transplantation, a procedure that carries considerable challenges and numerous ...
Oluwaseun O. Babatunde, Madeleine G. Bibby, Anthony Atala, Graça Almeida‐Porada, Christopher D. Porada   +4 more
wiley   +1 more source

Natural Polysaccharides for Rheumatoid Arthritis Therapy: Mechanism, Drug Delivery and Clinical Application

Phytotherapy Research, EarlyView.
Schematic overview of the experimental models, therapeutic mechanisms, drug delivery systems, and clinical potential of natural polysaccharides in rheumatoid arthritis. ABSTRACT Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized primarily by chronic synovitis.
Luxin Li, Junnan Li, Guangzhi Li, Lili Huang, Tiantian Wen, Yanying Li, Yan Sun, Zhenqiang Liu, Qingshan Chen, Lili Zhang, Tiangang Lu, Ruiyan Wu, Haixue Kuang, Xiaochi Ma, Yan Liu   +14 more
wiley   +1 more source

Reasoning Together or Clicking Through? Analyzing Patterns of Group Science Talk On and Off Individualized Computers

Science Education, EarlyView.
ABSTRACT In this article, I examine group science talk within the classrooms of three urban secondary science teachers who regularly use one‐to‐one computers to mediate their NGSS‐aligned science instruction. I combine methods of framing analysis (Goffman 1974; Tannen 1993) and interaction analysis (Jordan and Henderson 1995) to illustrate differences ...
Tess Bernhard
wiley   +1 more source

Neurotrophic Signaling, Sleep Physiology, and Retinal Neuroprotection: Integrative Mechanisms and Therapeutic Implications for Glaucoma

Sensory Neuroscience, EarlyView.
Glaucoma is increasingly understood as a neurodegenerative disorder shaped by sleep and circadian physiology, not intraocular pressure alone. Sleep loss and obstructive sleep apnea suppress BDNF–TrkB neurotrophic signaling, impair sleep‐dependent glymphatic clearance, and trigger microglial neuroinflammation and vascular insult at the optic nerve head,
Karyme M. Alemán‐Villa, Emiliano Terán, Javier A. Magaña‐Gómez, Loranda Calderón‐Zamora, Beatriz K. De la Herrán‐Arita, Alberto K. De la Herrán‐Arita   +5 more
wiley   +1 more source

A Biomimetic Breast Tumor‐On‐Chip Platform Reveals Mesenchymal Marker Upregulation Following Gold Nanorod Photothermal Therapy

Small, EarlyView.
A biomimetic microfluidic tumor‐on‐chip platform was designed to uncover subtype‐dependent responses to nanoparticle‐mediated photothermal therapy in breast cancer spheroids. The platform establishes a physiologically relevant and controllable 3D system for precision evaluation of nanophotothermal cancer therapies.
Camila A. Salvego, Hasti Honari, Anastasiia Dubrova, Stéphanie Descroix, Martha S. Ribeiro, Aurore V. Walle, Claire Wilhelm   +6 more
wiley   +1 more source

[The isolation and characteristics of monoclonal antibodies to recombinant proteins of HIV-1 and HIV-2--the env and gag gene products].

Voprosy virusologii, 1994
Ten hybridomas secreting monoclonal antibodies (Mab) against recombinant HIV-1 and HIV-2 antigens were produced (3 Mab anti-gag protein, 2 anti-env1, and 5 anti-env2). In the immunoblotting assay all the anti-gag Mabs reacted with HIV capsid protein p24, whereas one of them reacted also with p55 protein and with 7 other polypeptides.
A V, Pugach, V V, Zverev, E R, Pille, N R, Shukhmina, N L, Mel'nikova, D N, Nosik, V V, Maliushova, O G, Andzhaparidze   +7 more
openaire   +1 more source

Targeting the CD47–SIRPα phagocytic checkpoint in cancer: Biology, translational opportunities, and next‐generation therapeutic strategies

Smart Molecules, EarlyView.
The CD47–SIRPα axis has emerged as a critical innate immune checkpoint that suppresses macrophage‐mediated phagocytosis through a canonical “don't eat me” signal and enables tumor immune evasion. We comprehensively summarize the structural and biological features of CD47 and the molecular mechanisms underlying CD47‐mediated regulation of phagocytosis ...
Ruimei Zhou, Lingjie Jing, Jianping Zhang, Cheng Guo, Quanjun Yang   +4 more
wiley   +1 more source

Research Progress on Thermal Runaway and Thermal Management of Lithium‐Ion Batteries

Safety Science and Technology, EarlyView.
This review summarizes thermal runaway mechanisms, propagation pathways, mitigation strategies, and intelligent thermal management technologies for lithium‐ion batteries, highlighting the transition from passive heat dissipation to integrated safety regulation through advanced cooling, barrier materials, sensing, machine learning, and digital‐twin ...
Songrong Li, Wenjia Zhao, Yutong Zhang, Xianyong Wu, Zhongxue Chen   +4 more
wiley   +1 more source

An Outline of a Theory of Play

Symbolic Interaction, EarlyView.
Play is often dismissed as trivial, yet it is a fundamental and adaptive aspect of human and mammalian life. This paper develops a sociological theory of play, treating it as a total social fact that spans biological, psychological, and social dimensions.
Seth Abrutyn
wiley   +1 more source