Results 321 to 330 of about 271,468 (359)

Gene Rearrangements in Lymphoma

The American Journal of Dermatopathology, 1987
Clonality is regarded as an important diagnostic feature of B-cell lymphomas, but until recently the clonality of T-cell proliferations could not be directly determined. Elucidation of the genetic events in lymphocytic differentiation has led to the development of an assay for clonality in both B- and T-cell infiltrates.
P E, LeBoit, T G, Parslow
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The arrangement and rearrangement of antibody genes

Nature, 1978
Cloned segments of mouse chromosomal DNA provide direct evidence for the somatic rearrangement of kappa variable and constant region genes in antibody producing cells. This rearrangement apparently affects only one member of an allelic pair of light chain genes.
Seidman, J G, Leder, P
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Antigen receptor gene rearrangement

Current Opinion in Immunology, 1998
Two specialized forms of site-directed double-strand (ds) DNA breakage and rejoining are part of the physiologic program of lymphocytes. One is recombination of the V, D and J gene sequences, termed V(D)J recombination, occurring during early B- and T-cell development, and the other is class-switch recombination occurring exclusively in mature B cells.
U, Grawunder, R B, West, M R, Lieber
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Gene rearrangements in malignant lymphomas

1993
Diagnosis and classification of malignant lymphomas is one of the most difficult and challenging problems encountered by pathologists today. Techniques for molecular genetic analysis have added an entirely new dimension to our understanding of the biology of the normal immune response.
R M, Braziel, A R, Sacker
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The Role of Gene Rearrangement in Evolution

1979
Chromosomes are commonly regarded as conservative structures, in which an exact amount of genetic information is arranged in a definite sequential order. This order is normally preserved when information is exchanged between chromosomes, and guaranteed by a set of recombination enzymes that function only with paired sectors of homologous DNA.
H, Saedler, D, Ghosal, P, Nevers
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Gene rearrangement and the generation of diversity

Nature, 1982
THE eukaryotic genome has rececently begun to seem less stable, both in evolution1 and in ontogeny2, than many biologists had assumed. These trends prompted the Institute of Genetics to invite to its annual Spring meeting* speakers on six genetically labile systems: the MHC locus and the immunoglobulin genes of mammals, the genes encoding the surface ...
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Gene Rearrangements Testing

2012
The B- and T-cell gene rearrangement test is one of the hallmarks of the molecular pathology diagnostic laboratories. Historically done with Southern blot and now adopted by many laboratories using PCR, the test is used as an aid in pathology diagnosis to distinguish between benign lymphoproliferative disorders, usually polyclonal, and clonally derived
Siby Sebastian, Juan Du, Rizwan Naeem
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Rearrangement of immunoglobulin genes

Biochemistry, 1979
Wilson, R, Miller, J, Storb, U
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The rearrangements of immunoglobulin genes

Trends in Biochemical Sciences, 1981
Abstract Antibodies are encoded by a complex gene system that apparently undergoes unprecedented rearrangements during lymphocyte development. The immunoglobulin gene system has evolved novel and flexible strategies for dealing with large amounts of genetic information.
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Cancer epigenetics in clinical practice

Ca-A Cancer Journal for Clinicians, 2023
Veronica Davalos, Manel Esteller
exaly