Results 251 to 260 of about 631,661 (355)

Genetic Modifiers of Parkinson's Disease: A Case–Control Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the associations of LRRK2 p.G2019S, GBA1 p.N409S, polygenic risk scores (PRS), and APOE E4 on PD penetrance, risk, and symptoms. Methods We conducted a US‐based observational case–control study using data from the 23andMe Inc. and Fox Insight Genetic Substudy (FIGS) databases.
Matthew J. Kmiecik, Michael V. Holmes, Pierre Fontanillas, Giulietta M. Riboldi, Ruth B. Schneider, Jingchunzi Shi, Anna Guan, Susana Tat, Steven Micheletti, Keaton Stagaman, Josh Gottesman, David A. Hinds, Joyce Y. Tung, 23andMe Research Team, Stella Aslibekyan, Lucy Norcliffe‐Kaufmann   +15 more
wiley   +1 more source

Construction of anti-tumor immune gene signature for HNSCC and identification of 4'-Hydroxywogonin as a potential immunotherapy combination drug. [PDF]

Cancer Cell Int
Qiang W, Dai Y, Wang L, Wang J, Ge W.
europepmc   +1 more source

Assessing a Mitochondrial Disease Treatment via a Novel Statistical Technique for Accelerometer Data

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Therapeutic development for mitochondrial diseases, rare genetic disorders with pathogenic defects of oxidative phosphorylation, is hindered by unsatisfactory outcome measures. To address this problem, we provide the first clinical application of a novel, bias‐adjusted outcome measure of acceleration across a range of subjects ...
Ian W. McKeague, Kristin Engelstad, Yue Ge, Amber Tucker, Shufang Li, Jasim Uddin, Ziwei Zhao, John L. P. Thompson, Michio Hirano   +8 more
wiley   +1 more source

Intra-tumor heterogeneity-resistant gene signature predicts prognosis and immune infiltration in breast cancer. [PDF]

Front Immunol
Shen H, Zheng Q, Pan J, Jin Y, Zheng X, Yuan Q, Tan D, Zhou Q, Wang J, Sun T.   +9 more
europepmc   +1 more source

Identification of T Cell-Restricted Genes, and Signatures for Different T Cell Responses, Using a Comprehensive Collection of Microarray Datasets

, 2005
Tatyana Chtanova, Rebecca Newton, Sue Min Liu, Lilach Weininger, Timothy R. Young, Diego G. Silva, Francesco Bertoni, Andrea Rinaldi, Stéphane Chappaz, Federica Sallusto, Michael S. Rolph, Charles R. Mackay   +11 more
openalex   +1 more source

Exploring Nasal Structural‐Microbial Interactions in Multiple Sclerosis‐Associated Olfactory Impairment

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Olfactory dysfunction is frequently observed in patients with multiple sclerosis (MS); however, its underlying mechanisms remain poorly understood. To date, no studies have directly examined the nasal mucosal microbiota in MS. This study aimed to explore potential relationships among olfactory function, nasal microbiota composition,
Zidan Gao, Zhuoma Danzhen, Yao Li, Junyu Zhu, Lan Chu, Zhang Yang   +5 more
wiley   +1 more source

Deciphering the lactylation landscape in glioma: a novel gene signature predicts patient survival and immunotherapy sensitivity. [PDF]

Front Immunol
Tang X, Liu Y, Yang C, Zhang H, Zhang G, Wang Q, Jiang S, Gao X, Liu Y, Dong Y.   +9 more
europepmc   +1 more source

Detection of the placental epigenetic signature of the maspin gene in maternal plasma

, 2005
S Chim, Tong Yu, Rossa W. K. Chiu, Tze Kin Lau, Tse Ngong Leung, Lisa Chan, Cees B.M. Oudejans, Chunming Ding, Y. M. Dennis Lo   +8 more
openalex   +1 more source

CSF Mitochondrial DNA: Biomarker of Body Composition and Energy Metabolism in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cerebrospinal fluid (CSF) cell‐free mitochondrial DNA (cf‐mtDNA) is a potential biomarker for Parkinson's disease (PD), but its clinical relevance remains unclear. We investigated associations between CSF cf‐mtDNA levels, body composition, nutritional status, and metabolic biomarkers in PD. Methods CSF cf‐mtDNA levels, defined as the
Yasuaki Mizutani, Tsuyoshi Nakai, Yasuhiro Maeda, Reiko Ohdake, Atsuhiro Higashi, Toshiki Maeda, Ryunosuke Nagao, Sayuri Shima, Kazuya Kawabata, Akihiro Ueda, Mizuki Ito, Hirohisa Watanabe   +11 more
wiley   +1 more source

Corrigendum: Reducing MYC's transcriptional footprint unveils a good prognostic gene signature in melanoma. [PDF]

Genes Dev
Zacarías-Fluck MF, Massó-Vallés D, Giuntini F, González-Larreategui Í, Kaur J, Casacuberta-Serra S, Jauset T, Martínez-Martín S, Martín-Fernández G, Del Pozo ES, Foradada L, Grueso J, Nonell L, Beaulieu ME, Whitfield JR, Soucek L.   +15 more
europepmc   +1 more source