Results 321 to 330 of about 631,661 (355)
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Gene Signatures in the Management of Hepatocellular Carcinoma
Seminars in Oncology, 2012Clinical management of hepatocellular carcinoma (HCC) is a complex process. Currently existing prognostic staging systems have substantially improved the clinical outcome of patients by guiding treatment decision and allocation of medical resources.
Clara Alsinet +7 more
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Horizontal Gene Transfer in Cyanobacterial Signature Genes
2009Comparison of 15 phylogenetically diverse cyanobacterial genomes identified an updated list of 183 signature genes that are widely found in cyanobacteria but absent in non-cyanobacterial species. These signature genes comprise the unique portion of the core cyanobacterial phenotype, and their absence from other lineages implies that if they arose by ...
Shailaja Yerrapragada +2 more
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Scleroderma gene expression and pathway signatures
Current Rheumatology Reports, 2008Gene expression studies in scleroderma have shown large and consistent changes in the gene expression of end-target tissues. These changes reflect the lymphocyte infiltration and pathway deregulation potentially linked to disease pathogenesis. Gene expression in scleroderma also reflects the clinical heterogeneity in the disease and can be used to ...
Jennifer L. Sargent +3 more
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Gene expression analysis by signature pyrosequencing
Gene, 2002We describe a novel method for transcript profiling based on high-throughput parallel sequencing of signature tags using a non-gel-based microtiter plate format. The method relies on the identification of cDNA clones by pyrosequencing of the region corresponding to the 3'-end of the mRNA preceding the poly(A) tail.
Jacob Odeberg +8 more
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A gene expression signature for insulin resistance
Physiological Genomics, 2011Insulin resistance is a heterogeneous disorder caused by a range of genetic and environmental factors, and we hypothesize that its etiology varies considerably between individuals. This heterogeneity provides significant challenges to the development of effective therapeutic regimes for long-term management of type 2 diabetes.
Konstantopoulos, Nicky +19 more
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Gene-Expression Signatures in Oncology Diagnostics
Pharmacogenomics, 2006The advent of DNA microarray technologies has enabled the development of gene expression signatures that can be used for prognostic and predictive purposes. This new information can change the paradigm of how medicine is practiced, coupling physical examination, pathology and clinical tests with new molecular information.
Yixin Wang, Abhijit Mazumder
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Common gene signature of cancer and longevity
Mechanisms of Ageing and Development, 2009An association between aging/longevity and cancer has long been suggested, yet the evolutionary and molecular links between these complicated traits remain elusive. Here, we analyze the relationship between longevity- and cancer-associated genes/proteins (LAGs/LAPs and CAGs/CAPs, respectively).
Marina Wolfson +5 more
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Gene-Expression Signatures in Breast Cancer
New England Journal of Medicine, 2009Gene-expression profiling with the use of DNA microarrays allows measurement of thousands of messenger RNA (mRNA) transcripts in a single experiment. Results of such studies have confirmed that breast cancer is not a single disease with variable morphologic features and biomarkers but, rather, a group of molecularly distinct neoplastic disorders ...
Sotiriou, Christos, Pusztai, Lajos
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Gene expression signatures in lymphoid tumours
Immunology & Cell Biology, 2004Lymphoid tumours comprise the acute and chronic leukaemias, the broad spectrum of lymphomas, including Hodgkin's disease, and multiple myeloma. The subdivision of the acute leukaemias according to the proliferating type of white blood cells has had a major impact on the care of these patients.
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Der Pathologe, 2011
This review reports the main gene signature specific for the diagnosis, prognosis or prediction of drug response in sarcomas. Almost half of sarcomas show a simple genetic lesion which is specific for the diagnosis: recurrent translocations in 10 to 15% of sarcomas, specific activating and inactivating mutations in GIST and rhabdoid tumor respectively,
Coindre Jm, Chibon F
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This review reports the main gene signature specific for the diagnosis, prognosis or prediction of drug response in sarcomas. Almost half of sarcomas show a simple genetic lesion which is specific for the diagnosis: recurrent translocations in 10 to 15% of sarcomas, specific activating and inactivating mutations in GIST and rhabdoid tumor respectively,
Coindre Jm, Chibon F
openaire +3 more sources