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Gene targeting of retinoid receptors
Molecular Biotechnology, 1998Gene targeting in embryonic stem (ES) cells has been employed to investigate the role of the retinoid receptors and binding proteins both in the mouse as well as in embryocarcinoma cells. It is a powerful technique for the modification of the mouse genome.
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Gene targeting in hemostasis. plasminogen
Frontiers in Bioscience, 2001A number of in vitro and in vivo observations have implicated plasminogen in contributing to events associated with diverse physiological and pathophysiological processes. The development of gene knockout technology has led to the generation of plasminogen deficient mice.
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Targeting Ochratoxin Biosynthetic Genes
2016The pathway of ochratoxin A (OTA) biosynthesis has not yet been completely elucidated. Essentially, two kind of genes have been demonstrated to be involved in the biosynthesis of OTA. One of them is the nrps gene encoding a non-ribosomal peptide synthetase (NRPS) which catalyzes the ligation between the isocoumarin group, constituting the polyketide ...
Gallo Antonia, Perrone Giancarlo
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2012
Publisher Summary This chapter summarizes the historic background and the current state of gene targeting technology with specific regard to neuroscience research. Random mutagenesis is a very powerful method for elucidating gene function in simpler model organisms.
Mario R. Capecchi, Petr Tvrdik
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Publisher Summary This chapter summarizes the historic background and the current state of gene targeting technology with specific regard to neuroscience research. Random mutagenesis is a very powerful method for elucidating gene function in simpler model organisms.
Mario R. Capecchi, Petr Tvrdik
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Targeting the “species gene ensemble”
Hippocampus, 2002AbstractThe members of a given species display a normal distribution of gene expression which is here termed the species gene ensemble. This more specific designation of the ‘genetic background’ leads to a consideration of why gene targeting outcomes are regulated by the species gene ensemble. One consequence is the utility of the heterozygous knockout
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Target genes of homeodomain proteins
BioEssays, 1999Homeodomain proteins are transcription factors that share a related DNA binding domain, the homeodomain. This class of proteins was first recognized in the fruitfly Drosophila melanogaster where they cause homeotic transformations such as a fly with four wings instead of two (Lewis EB. A gene complex controlling segmentation in Drosophila.
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Conditional gene targeting in macrophages and granulocytes using LysMcre mice
Transgenic research, 1999B. Clausen +4 more
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