Results 391 to 400 of about 12,185,719 (426)
Some of the next articles are maybe not open access.
2012
Publisher Summary This chapter summarizes the historic background and the current state of gene targeting technology with specific regard to neuroscience research. Random mutagenesis is a very powerful method for elucidating gene function in simpler model organisms.
Mario R. Capecchi, Petr Tvrdik
openaire +2 more sources
Publisher Summary This chapter summarizes the historic background and the current state of gene targeting technology with specific regard to neuroscience research. Random mutagenesis is a very powerful method for elucidating gene function in simpler model organisms.
Mario R. Capecchi, Petr Tvrdik
openaire +2 more sources
Targeting the “species gene ensemble”
Hippocampus, 2002AbstractThe members of a given species display a normal distribution of gene expression which is here termed the species gene ensemble. This more specific designation of the ‘genetic background’ leads to a consideration of why gene targeting outcomes are regulated by the species gene ensemble. One consequence is the utility of the heterozygous knockout
openaire +3 more sources
Target genes of homeodomain proteins
BioEssays, 1999Homeodomain proteins are transcription factors that share a related DNA binding domain, the homeodomain. This class of proteins was first recognized in the fruitfly Drosophila melanogaster where they cause homeotic transformations such as a fly with four wings instead of two (Lewis EB. A gene complex controlling segmentation in Drosophila.
openaire +3 more sources
Conditional gene targeting in macrophages and granulocytes using LysMcre mice
Transgenic research, 1999B. Clausen +4 more
semanticscholar +1 more source
Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells
Cell, 1987K. Thomas, M. Capecchi
semanticscholar +1 more source
Targeting cancer metabolism in the era of precision oncology
Nature Reviews Drug Discovery, 2022Arantxa Gorostiaga +2 more
exaly