Results 211 to 220 of about 1,108,606 (318)

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

Progress in Gene Therapy for Hereditary Tyrosinemia Type 1. [PDF]

Pharmaceutics
Thomas H, Carlisle RC.
europepmc   +1 more source

Gene therapy to promote thromboresistance: Local overexpression of tissue plasminogen activator to prevent arterial thrombosis in an in vivo rabbit model [PDF]

, 1999
Jacob M. Waugh, Maan Kattash, J. Li, E. Yüksel, Michael Kuo, M. Lussier, Adam B. Weinfeld, Renu Saxena, E. D. Rabinovsky, Swan N. Thung, Savio L.C. Woo, Saleh M. Shenaq   +11 more
openalex   +1 more source

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

Gene therapy breakthroughs in ALS: a beacon of hope for 20% of ALS patients. [PDF]

Transl Neurodegener
Xie Q, Li K, Chen Y, Li Y, Jiang W, Cao W, Yu H, Fan D, Deng B.   +8 more
europepmc   +1 more source

Immunotherapy / Gene therapy / AIDS and cancer

, 1992
Jean-Luc Darilx, Caroline Gabus, Chrtetophe Laboretro   +2 more
openalex   +1 more source

Suicide gene therapy for plasma cell tumors [PDF]

, 1996
M. Siraç Dilber, MR Abedi, B. Björkstrand, Birger Christensson, Gösta Gahrton, K G Xanthopoulos, Smith Rjh   +6 more
openalex   +1 more source

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

Platelet-Targeted Gene Therapy for Hemophilia A with Inhibitor History. [PDF]

N Engl J Med
Eapen M, Malec LM, Armant MA, Johnson BD, Shi Q, Xu H, Du LM, Jerkins JH, Duffy LJ, Bushman FD, Lee C, Petrichenko A, Hematti P, Brazauskas R, Jobe SM, Hari PN, Wilcox DA.   +16 more
europepmc   +1 more source

GENE THERAPY FOR LEUKEMIA AND LYMPHOMA

, 1998
Scott W. Adams, Stephen G. Emerson
openalex   +1 more source