Results 241 to 250 of about 12,497,887 (407)

Getting closer to hemophilia gene therapy for all? [PDF]

Blood Adv
Reiss UM.
europepmc   +1 more source

Fetal gene therapy under the microscope...

, 1994
Helen Gavaghan
openalex   +1 more source

Systemic gene therapy: biodistribution and long-term expression of a transgene in mice. [PDF]

, 1995
Alain R. Thierry, Yanto Lunardi-Iskandar, Joseph Bryant, P Rabinovich, R C Gallo, L C Mahan   +5 more
openalex   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Brain‐derived neurotrophic factor gene therapy prevents spiral ganglion degeneration after hair cell loss [PDF]

, 1998
Hinrich Staecker, Ramin Gabaizadeh, Howard J. Federoff, Thomas R. Van De Water   +3 more
openalex   +1 more source

Gene therapy comes of age

Science, 2018
C. Dunbar, K. High, J. Joung, D. Kohn, K. Ozawa, M. Sadelain   +5 more
semanticscholar   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Gene therapy and genome editing for lipoprotein disorders. [PDF]

Eur Heart J
Gurevitz C, Bajaj A, Khera AV, Do R, Schunkert H, Musunuru K, Rosenson RS.   +6 more
europepmc   +1 more source

BCL-6 Gene Mutations in Posttransplantation Lymphoproliferative Disorders Predict Response to Therapy and Clinical Outcome [PDF]

, 1998
Ethel Cesarman, Amy Chadburn, Yifang Liu, Anna Migliazza, Riccardo Dalla‐Favera, Daniel M. Knowles   +5 more
openalex   +1 more source

Multi‐omic profiling of squamous cell lung cancer identifies metabolites and related genes associated with squamous cell carcinoma

Molecular Oncology, EarlyView.
Using multi‐omic characterization, we aimed to identify key regulators specific to squamous cell lung carcinoma (SqCC). SqCC‐specific differentially expressed genes were integrated with metabolics data. High expression of the creatine transporter SLC6A8, along with elevated creatine levels, appeared to be a distinct metabolic feature of SqCC.
Johan Staaf, Daniel Ehinger, Hans Brunnström, Mats Jönsson, Frida Rosengren, Marija Kotevska, Anna Karlsson, Mattias Aine, Christian Frezza, Maria Planck, Elsa Arbajian   +10 more
wiley   +1 more source