Results 261 to 270 of about 2,093,614 (359)

The Impact of QSP Modeling on the Design and Optimization of Gene Therapy Approaches. [PDF]

CPT Pharmacometrics Syst Pharmacol
Rayad N, Chowdhury EA, Meno-Tetang GML.
europepmc   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Gene Therapy and Epigenetic Modulation in Chronic Pain: A Future Without Opioids? [PDF]

Cureus
Idahor CO, Okorie MA, Mokobia S, Erhuanga P, Ogbonna N, Ogunfuwa O, Etoroma OM, Abhulimen IJ, Chinedu E.   +8 more
europepmc   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Navigating the Hurdles of Intra-Articular AAV Gene Therapy. [PDF]

Int J Mol Sci
Li W, Thornton O, Feng S, Li C.
europepmc   +1 more source

Improving adenoviral vectors and strategies for prostate cancer gene therapy

, 2018
Rodrigo Esaki Tamura, Igor Vieira de Luna, Marlous G. Lana, Bryan E. Strauss   +3 more
openalex   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Toward Precision Medicine: Gene Therapy Applications in the Management of Uveal Melanoma. [PDF]

Cancer Rep (Hoboken)
Azani A, Ghassemifar V, Mehrdad Z, Saberivand M, Bagheripour A, Tahmasebi S, Gharedaghi H, Sharafi M, Foroozand H, Soleimani Meigoli MS, Pourali S, Salmaninejad A, Ahmadi Beni F, Behfar Q.   +13 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Getting closer to hemophilia gene therapy for all? [PDF]

Blood Adv
Reiss UM.
europepmc   +1 more source