Results 261 to 270 of about 12,497,887 (407)

Application of Gene Therapy to Oral Diseases. [PDF]

Pharmaceutics
Yamano S, Inoue K, Taguchi Y.
europepmc   +1 more source

Towards Somatic Gene Therapy of Hemophilia B

, 1992
Yukinori Kurachi
openalex   +2 more sources

Keratinocyte gene therapy for systemic diseases. Circulating interleukin 10 released from gene-transferred keratinocytes inhibits contact hypersensitivity at distant areas of the skin. [PDF]

, 1998
Xianzhi Meng, Daisuke Sawamura, Katsuto Tamai, K Hanada, Hiroshi Ishida, Isao Hashimoto   +5 more
openalex   +1 more source

Gene Therapy in Patients with Transfusion‐Dependent β‐Thalassemia

New England Journal of Medicine, 2018
A. Thompson, M. Walters, J. Kwiatkowski, J. Rasko, J. Ribeil, S. Hongeng, E. Magrin, G. Schiller, E. Payen, M. Semeraro, D. Moshous, F. Lefrère, H. Puy, P. Bourget, A. Magnani, L. Caccavelli, J. Diana, F. Suarez, F. Monpoux, V. Brousse, C. Poirot, C. Brouzes, J. Meritet, C. Pondarré, Y. Beuzard, S. Chrétien, T. Lefèbvre, D. Teachey, U. Anurathapan, P. Ho, C. von Kalle, M. Kletzel, E. Vichinsky, S. Soni, G. Veres, O. Nègre, R. W. Ross, D. Davidson, Alexandria Petrusich, L. Sandler, M. Asmal, O. Hermine, M. de Montalembert, S. Hacein-Bey-Abina, S. Blanche, P. Leboulch, M. Cavazzana   +46 more
semanticscholar   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Immunotherapy / Gene therapy / AIDS and cancer

, 1992
Jean-Luc Darilx, Caroline Gabus, Chrtetophe Laboretro   +2 more
openalex   +1 more source

Suicide gene therapy for plasma cell tumors [PDF]

, 1996
M. Siraç Dilber, MR Abedi, B. Björkstrand, Birger Christensson, Gösta Gahrton, K G Xanthopoulos, Smith Rjh   +6 more
openalex   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

AAV for ovarian cancer gene therapy. [PDF]

Cancer Gene Ther
Yoo HC, Lee S, Park JY, Lee EJ.
europepmc   +1 more source