Results 341 to 350 of about 12,497,887 (407)

Berberine–cinnamic acid co‐crystal effect in ameliorating hyperlipidemia might be regulated through the PI3K/AKT/mTOR/SREBP‐1 signaling pathway

FEBS Open Bio, EarlyView.
Berberine–cinnamic acid co‐crystal (BBR‐CA) inhibits the phosphorylation of the phosphatidylinositol 3‐kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway, suppressing the transfer of pre‐sterol regulatory element‐binding proteins‐1 (SREBP‐1) from the endoplasmic reticulum to the nucleus. This results in a decrease in the expression level of
Wenheng Gao, Yunlong Li, Lihua Chen, Wenshuo Yang, Yong He, Ye Yang, Dengke Yin, Song Tan   +7 more
wiley   +1 more source

Safety through design: Expanding options for spinal muscular atrophy gene therapy. [PDF]

Mol Ther Methods Clin Dev
Groen EJN, Wadman RI.
europepmc   +1 more source

The impact of Hnrnpl deficiency on transcriptional patterns of developing muscle cells

FEBS Open Bio, EarlyView.
We performed nanopore whole‐transcriptome sequencing comparing RNA from Hnrnpl‐knockdown versus control C2C12 myoblasts to investigate the contributions of Hnrnpl to muscle development. Our results indicate that Hnrnpl regulates the expression of genes involved with Notch signaling and skeletal muscle, particularly splicing patterns of specific muscle ...
Hannah R. Littel, Mekala Gunasekaran, Audrey L. Daugherty, Natalya M. Wells, Johnnie Turner, Christine C. Bruels, Christina A. Pacak, Isabelle Draper, Peter B. Kang   +8 more
wiley   +1 more source

The promise of gene therapy in common types of dementia. [PDF]

Bioimpacts
Ghobadi M, Heidari MF, Farhadi A, Shakerimoghaddam A, Ghorbani M, Hami Z, Ehtesham N, Behroozi J.   +7 more
europepmc   +1 more source

Mitochondria‐associated membranes (MAMs): molecular organization, cellular functions, and their role in health and disease

FEBS Open Bio, EarlyView.
Mitochondria‐associated membranes (MAMs) are contact sites between the endoplasmic reticulum and mitochondria that regulate calcium signaling, lipid metabolism, autophagy, and stress responses. This review outlines their molecular organization, roles in cellular homeostasis, and how dysfunction drives neurodegeneration, metabolic disease, cancer, and ...
Viet Bui, Maryline Santerre, Natalia Shcherbik, Bassel E Sawaya   +3 more
wiley   +1 more source

Targets and Gene Therapy of ALS (Part 1). [PDF]

Int J Mol Sci
Shiryaeva O, Tolochko C, Alekseeva T, Dyachuk V.   +3 more
europepmc   +1 more source

Unlocking the potential: advancements and applications of gene therapy in severe disorders. [PDF]

Ann Med
Ingle RG, M Elossaily G, Ansari MN, Makhijani S.   +3 more
europepmc   +1 more source

Gene Therapy Approaches for Atherosclerosis Focusing on Targeting Lipid Metabolism and Inflammation. [PDF]

Int J Mol Sci
Bezsonov E, Chernyi N, Saruhanyan M, Shimchenko D, Bondar N, Gavrilova D, Baig MS, Malogolovkin A.   +7 more
europepmc   +1 more source

Developing a minimally invasive gene therapy for multiple sclerosis. [PDF]

Mol Ther Methods Clin Dev
Nijhuis PJH, Romijn M, Honing R, van Zon G, Huitinga I, de Winter F, Verhaagen J.   +6 more
europepmc   +1 more source

Case Report: Eltrombopag in mosaic and gene therapy-treated patients with Fanconi anemia. [PDF]

Front Pediatr
Zubicaray J, Iriondo J, Sebastián E, Sanz A, Rio P, Soulier J, San Román S, Uriz JJ, Navarro S, Nicoletti E, Bueren JA, Schwartz JD, Sevilla J.   +12 more
europepmc   +1 more source