Results 171 to 180 of about 305,994 (296)

IS<i>1216</i> drives the evolution of pRUM-like multidrug resistance plasmids in <i>Enterococcus faecium</i>. [PDF]

Microb Genom
Allen F, McInnes RS, van Schaik W, Moran RA.   +3 more
europepmc   +1 more source

Lactylation Enhances the Activity of Lactate Dehydrogenase A and Promotes the Chemoresistance to Cisplatin Through Facilitating DNA Nonhomologous End Junction in Lung Adenocarcinoma

Advanced Science, EarlyView.
Lactylation, linked to glycolysis, is poorly understood in regulation. It is found that LDHA is lactylated at Lys81/Lys318 by AARS1, boosting its activity and cellular lactylation via positive feedback in LUAD. Lactylation regulates NHEJ‐related proteins; their delactylation impairs NHEJ and increases cisplatin sensitivity, offering anticancer insights.
Jizhuo Li, Wenze Xun, Xijie Wang, Ruiguang Luo, Qifan Hu, Zhaocai Zhou, Jian Yuan, Yanan Wang, Xiaorui Wan, Tao Zhao, Tianyu Han, Jian‐Bin Wang   +11 more
wiley   +1 more source

Possible Horizontal Gene Transfer of Novel Transposable Elements in <i>Anisakis simplex</i> between Hosts and Parasites. [PDF]

MicroPubl Biol
Hoshino N, Kuroda H.
europepmc   +1 more source

Correlative Imaging Platform Linking Taste Cell Function to Molecular Identity

Advanced Science, EarlyView.
A correlative imaging platform is developed to study how individual taste cells respond to different taste qualities. By linking cellular activity with molecular identity and environmental context, dual‐tuned taste cells capable of detecting both sweet and umami stimuli are identified.
Sungho Lee, Minjae Kim, Gha Yeon Park, Jubeen Yoon, Kunyoo Shin, Chang Ho Sohn, Myunghwan Choi   +6 more
wiley   +1 more source

Prevalence and stable acquisition of biogenic amine-synthesizing genes in lactic acid bacteria across diverse niches: implications for food safety and human health. [PDF]

NPJ Sci Food
Javaid A, Tabassum N, Karthikeyan A, Kim YM, Jung WK, Khan F.   +5 more
europepmc   +1 more source

KRAS Withdrawal in Cholangiocarcinoma Leads to Immune Infiltration and Tumor Regression

Advanced Science, EarlyView.
Cholangiocarcinoma (CCA) driven by oncogenic KRAS depends on its continuous activation for tumor maintenance. Using a conditional KRAS model, the authors show that turning off KRAS triggers rapid tumor regression accompanied by immune cell infiltration and cytokine release. The findings uncover a KRAS–senescence–immune signaling axis and highlight KRAS
Youwei Qiao, Matthew F. Yee, Chaitanya N. Parikh, Boyang Ma, Yueying Cao, Yu‐Huan Shih, Joae Qiong Wu, Marcus Ruscetti, Shun‐Qing Liang, Wen Xue   +9 more
wiley   +1 more source

Classifying Convergences in the Light of Horizontal Gene Transfer: Epaktovars and Xenotypes. [PDF]

Mol Biol Evol
McInerney JO.
europepmc   +1 more source

Allelic Variation in Maize Malate Dehydrogenase 7 Shapes Promoter Methylation and Banded Leaf and Sheath Blight Resistance

Advanced Science, EarlyView.
In this study maize chloroplastic malate dehydrogenase7 (ZmMDH7), is identified as a Rhizoctonia solani resistance gene in maize. ZmMDH7 is regulated by transcription factor ZmWRKY44 via pathogens challenge to elevate mitochondrial ROS and SA signaling pathway.
Luyang Wei, Junbin Chen, Chuang Liu, DanDan Liu, Meida Du, Shengfeng He, Wenyu Cheng, Vijai Bhadauria, You‐Liang Peng, Wangsheng Zhu   +9 more
wiley   +1 more source

Erratum for Milhomem Pilati Rodrigues et al., "Experimental and evolutionary evidence for horizontal transfer of an envelope fusion protein gene between thogotoviruses and baculoviruses". [PDF]

J Virol
Milhomem Pilati Rodrigues B, Janssen L, da Silva LA, Acacio SSVG, Magalhães MT, Ribeiro BM.   +5 more
europepmc   +1 more source

'Informative' horizontal gene transfer [PDF]

Nature Biotechnology, 2004
Harry J Gilbert, Anthony G O'Donnell, John C Mathers   +2 more
openaire   +1 more source