Results 201 to 210 of about 305,994 (296)

Engineered GM1 Intersects Between Mitochondrial and Synaptic Pathways to Ameliorate ALS Pathology

Advanced Science, EarlyView.
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease driven by genetic and molecular disruptions affecting energy balance, protein homeostasis, and stress responses in nerve cells. Studies using human and rodent models identified convergent defects in mitochondria and synaptic function.
Federica Pilotto, Tristan Dellazizzo Toth, Silvano Bond, Alexander Schmitz, Rim Diab, Sara Y. Ngo Tenlep, Brian Mooney, Silvia Erni, Martina Schobesberger, Olivier Scheidegger, Camille Peitsch, Smita Saxena   +11 more
wiley   +1 more source

In-host co-colonization and bloodstream infection by distinct classical and hypervirulent CRKP clones harboring a homologous <i>bla</i> _KPC-2-harboring plasmid. [PDF]

Front Cell Infect Microbiol
Fang H, Chen Y, Chen Y, Qi Y, Yan R, Guo F.   +5 more
europepmc   +1 more source

Population‐Based Multi‐Omics and Cohort Study Identifying Predictive Biomarkers and Therapeutic Targets for Psoriatic Disease

Advanced Science, EarlyView.
Psoriatic disease (PsD) is a chronic skin disease, with challenges in early risk stratification and drug development. Through gene‐level causal inference framework and expression level validation, combined with longitudinal cohort study, CDSN and PRSS8 have been identified as candidate biomarkers and therapeutic targets for PsD.
Tianxing Wu, Jialiang Luo, Haoyuan Qiu, Weijie Shao, Yueyang Lu, Meixuan Luo, Zhaofeng Lin, Yan Zhang, Libo Zhang, Hong Wang, Jia Zhou, Guangfeng Ruan, Peihua Cao, Daming Zuo   +13 more
wiley   +1 more source

Genomic Characterization of a Class 2/1 Hybrid Integron-Driven Multidrug-Resistant <i>Proteus mirabilis</i> SH-8 of Swine Origin. [PDF]

Vet Sci
Wang X, Su H, Xu N, Tang D, Liu S, Lin J, Sha W, Yin B, Dong W.   +8 more
europepmc   +1 more source

Pre‐Existing Th1 Immunity Outperforms Age in Predicting Antibody Responses to SARS‐CoV‐2 Inactivated Vaccines

Advanced Science, EarlyView.
Challenging the focus on age, this study finds pre‐existing T helper 1 cells are the key biomarker for predicting antibody response to SARS‐CoV‐2 inactivated vaccines. In both mice and humans, high responders exhibited elevated baseline T helper 1 cells, which correlated with robust humoral immunity, offering crucial guidance for improving vaccine ...
Chanyuan Ye, Xiaoli Zhang, Lingfeng Qiu, Jia Ji, Jueqing Gu, Hongyu Jia, Yingfeng Lu, Jiyang Chen, Zelu Meng, Jiangshan Lian, Hangping Yao, Xun Zeng, Yida Yang   +12 more
wiley   +1 more source

Horizontal gene transfer, segregation loss, and the speed of microbial adaptation. [PDF]

Evol Lett
McLeod DV, Gandon S.
europepmc   +1 more source

OPTRACE: Optical Imaging–Guided Transplantation and Tracking of Cells in the Mouse Brain

Advanced Science, EarlyView.
OPTRACE establishes an optical, two‐step platform for intracerebral cell therapy. Transparent glass pipettes enable real‐time, image‐guided delivery, while multiplex genetic labeling with two‐photon and bioluminescence readouts supports longitudinal single‐cell tracking and host–graft dynamics.
Jinghui Wang, Honglin Tan, Colleen Russell, Mikolaj Walczak, Dawei Gao, Guanda Qiao, Xiaoxuan Fan, Chengyan Chu, Miroslaw Janowski, Piotr Walczak, Yajie Liang   +10 more
wiley   +1 more source

Identification of Outer Membrane Vesicles as a New Vehicle Mediating Antibiotic Resistance Gene Transfer in Campylobacter. [PDF]

J Extracell Vesicles
Zhao M, He M, Lin X, Wu K, Yang F, Chen X, Li H, Wang H, Tang Y.   +8 more
europepmc   +1 more source

HiST: Histological Images Reconstruct Tumor Spatial Transcriptomics via MultiScale Fusion Deep Learning

Advanced Science, EarlyView.
HiST, a multiscale deep learning framework, reconstructs spatially resolved gene expression profiles directly from histological images. It accurately identifies tumor regions, captures intratumoral heterogeneity, and predicts patient prognosis and immunotherapy response.
Wei Li, Dong Zhang, Eryu Peng, Shijun Shen, Hamid Alinejad‐Rokny, Yao Liu, Junke Zheng, Cizhong Jiang, Youqiong Ye   +8 more
wiley   +1 more source

Plasmid transmission dynamics and evolution of partner quality in a natural population of <i>Rhizobium leguminosarum</i>. [PDF]

mBio
Vereau Gorbitz D, Schwarz CP, McMullen JG, Cerón-Romero M, Doyle RT, Lau JA, Whitaker RJ, Vanderpool CK, Heath KD.   +8 more
europepmc   +1 more source