Results 51 to 60 of about 898,857 (281)

Testing for polytomies in phylogenetic species trees using quartet frequencies

, 2018
Phylogenetic species trees typically represent the speciation history as a bifurcating tree. Speciation events that simultaneously create more than two descendants, thereby creating polytomies in the phylogeny, are possible.
Mirarab, Siavash, Sayyari, Erfan
core   +2 more sources

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Coalescent-based genome analyses resolve the early branches of the euarchontoglires [PDF]

, 2013
Despite numerous large-scale phylogenomic studies, certain parts of the mammalian tree are extraordinarily difficult to resolve. We used the coding regions from 19 completely sequenced genomes to study the relationships within the super-clade ...
A Criscuolo, Axel Janke, B Rannala, Björn M. Hallström, BM Hallström, BM Hallström, BM Hallström, BM Hallström, C Lanave, CA Russo, D Curnoe, DE Pumo, DE Wildman, DH Huson, G Churakov, G Jobb, H Shimodaira, H Shimodaira, Hans Ellegren, J Schmitz, JA van Dam, JC Avise, JE Janecka, JE McCormack, JFC Kingman, JH Degnan, JJ Fong, JO Kriegs, JP Townsend, K Katoh, KM Kjer, L Liu, L Liu, L Liu, LS Kubatko, M Dos Reis, MJ Novacek, MP Simmons, NM Jameson, PJ Waddell, RJ Asher, S Guindon, S Kumar, S Song, S Whelan, SV Edwards, TH Ogden, TK Seo, U Arnason, U Arnason, Vikas Kumar, WJ Murphy, WP Maddison   +52 more
core   +3 more sources

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Factors influencing the accuracy and precision in dating single gene trees

Peer Community Journal
Molecular dating is the inference of divergence time from genetic sequences. Knowing the time of appearance of a taxon sets the evolutionary context by connecting it with past ecosystems and species.
Louvel, Guillaume, Roest Crollius, Hugues   +1 more
doaj   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Incomplete lineage sorting and long-branch attraction confound phylogenomic inference of Pancrustacea

Frontiers in Ecology and Evolution
IntroductionThe phylogenetic relationships within Pancrustacea (including Crustacea and Hexapoda) remain elusive despite analyses using various molecular data sets and analytical approaches over the past decade.
Hiu Yan Yu, Ka Hou Chu, Ka Hou Chu, Ling Ming Tsang, Ka Yan Ma   +4 more
doaj   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

An analytical comparison of coalescent-based multilocus methods: The three-taxon case [PDF]

, 2012
Incomplete lineage sorting (ILS) is a common source of gene tree incongruence in multilocus analyses. A large number of methods have been developed to infer species trees in the presence of ILS.
Roch, Sebastien
core  

Determining species tree topologies from clade probabilities under the coalescent

, 2011
One approach to estimating a species tree from a collection of gene trees is to first estimate probabilities of clades from the gene trees, and then to construct the species tree from the estimated clade probabilities. While a greedy consensus algorithm,
Bernier, Louis, Feau, Nicolas, Frey, Pascal, Hamelin, Richard C., Vialle, Agathe   +4 more
core   +2 more sources