Results 101 to 110 of about 10,369,971 (317)

Формування предметного поля метафізичних категорій у просторі філософських ідей Пізньої схоластики / The Formation of the Subject Field of Metaphysical Categories in Terms of Philosophical Ideas of Late Scholastic

Актуальні питання суспільних наук та історії медицини, 2014
Skrytska Natalya. The Formation of the Subject Field of Metaphysical Categories in Terms of Philosophical Ideas of Late Scholastics. The article considers the nature of such metaphysical concepts as essence, being, God, substance, logical quantifier ...
Скрицька Наталія
doaj  

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Editorial No. 40

Praxis Filosófica, 2019
Editor General
doaj   +1 more source

Target-controlled infusion of remimazolam effect-site concentration for total intravenous anesthesia in patients undergoing minimal invasive surgeries

Frontiers in Medicine
BackgroundAlthough pharmacokinetic and pharmacodynamic models of remimazolam have been developed, their clinical application remains limited.
Jin Young Chon, Kwon Hui Seo, Jaesang Lee, Subin Lee   +3 more
doaj   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Depression, Anxiety and Glucose Metabolism in the General Dutch Population: The New Hoorn Study

, 2010
Vanessa Bouwman, Marcel C. Adriaanse, Esther van ‘t Riet, Frank J. Snoek, Joost Dekker, Giel Nijpels   +5 more
openalex   +2 more sources

How long are consultations in French general practice? [PDF]

, 2000
Jean-Yves Chambonet, P Barberis, V Peron
openalex   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

IoT based car accident detection and notification algorithm for general road accidents

, 2019
Shivani Sharma, Shoney Sebastian
openalex   +2 more sources