Results 111 to 120 of about 35,832,141 (372)
BioGRID: a general repository for interaction datasets
Access to unified datasets of protein and genetic interactions is critical for interrogation of gene/protein function and analysis of global network properties.
Chris Stark+5 more
semanticscholar +1 more source
Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican+7 more
wiley +1 more source
Generalizing the generalized Petersen graphs
AbstractThe generalized Petersen graphs (GPGs) which have been invented by Watkins, may serve for perhaps the simplest nontrivial examples of “galactic” graphs, i.e. those with a nice property of having a semiregular automorphism. Some of them are also vertex-transitive or even more highly symmetric, and some are Cayley graphs.
Sarazin, ML, Pacco, W, PREVITALI, ANDREA
openaire +4 more sources
Novel and unscrutinized immune entities of the zebrafish gut
Understudied cells of the zebrafish immune system include bona fide immune cells and epithelial (‐derived) cells with immune functions. Research focusing on zebrafish cells which demonstrate similarities to mammalian immune cell counterparts may help us understand the pathologies in which they are implicated. Currently available and advanced tools make
Audrey Inge Schytz Andersen‐Civil+5 more
wiley +1 more source
General purpose rocket furnace [PDF]
A multipurpose furnace for space vehicles used for material processing experiments in an outer space environment is described. The furnace contains three separate cavities designed to process samples of the widest possible range of materials and thermal ...
Aldrich, B. R., Whitt, W. D.
core +1 more source
Cancer cell death induced by the NAD antimetabolite Vacor discloses the antitumor potential of SARM1
Vacor, a compound converted into the toxic metabolite Vacor adenine dinucleotide (VAD) by the nicotinamide salvage pathway enzymes NAMPT and NMNAT2, exhibits antitumor activity by inducing rapid and complete NAD depletion. We report that Vacor toxicity is limited to cell lines expressing high levels of SARM1, a NAD glycohydrolase.
Giuseppe Ranieri+5 more
wiley +1 more source
Invariant generators for generalized distributions
The existence of invariant generators for distributions satisfying a compatibility condition with the symmetry algebra is proved.
Tudor S. Ratiu, Madeleine Jotz
openaire +3 more sources
Protein kinase FAM20C—when subcellular localization matters
FAM20C is a Golgi‐resident kinase that phosphorylates proteins along the entire secretory pathway. The presence of potential FAM20C substrates in the cytoplasm or nucleus raises the question of how the kinase and its substrates encounter each other. Protein kinases achieve signaling specificity through consensus sequence recognition and subcellular ...
Francesca Noventa, Mauro Salvi
wiley +1 more source
The concept of perturbative gauge invariance formulated exclusively by means of asymptotic fields is used to construct massive gauge theories. We consider the interactions of $r$ massive and $s$ massless gauge fields together with $(r+s)$ fermionic ghost
A. Aste+11 more
core +1 more source