Results 71 to 80 of about 113,505 (257)

The administrative law aspects of physical planning in the Republic of Serbia: Building permit issuing procedure [PDF]

Zbornik Radova: Pravni Fakultet u Novom Sadu, 2018
One of the fundamental characteristics of the administrative law norms is its multiplicity. Alongside the General Part of the Administrative Law (legal norms applying to the administrative bodies including legal situations when all the administrative ...
Martinović Aleksandar L.
doaj  

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Collecting facts and burden of proof in administrative procedure [PDF]

Zbornik Radova: Pravni Fakultet u Novom Sadu
Gathering facts and means of proof in administrative procedure provides the factual basis necessary for making an administrative decision. The process of collecting facts and means of proof in administrative procedure is determined by the principle of ...
Milkov Dragan L., Radošević Ratko S.
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

ADMINISTRATIVE JUSTICE IN POLAND

BRICS Law Journal, 2016
This article begins with an analysis of the development of administrative justice in Poland over the last centuries. In particular, the author examines administrative jurisdiction before 1918, when Poland regained its independence, the period of the ...
J. Turłukowski
doaj   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Pioglitazone plus (−)‐epigallocatechin gallate: a novel approach to enhance osteogenic performance in aged bone marrow mesenchymal stem cells

FEBS Open Bio, EarlyView.
Aged human bmMSCs are seeded in the scaffold. Osteoblastic induction can slightly increase cell's bone‐forming activity to produce bone‐like tissues, shown as the sporadic xylenol orange‐stained spots (the lower left image). Notably, pioglitazone plus EGCG co‐treatment dramatically increases cell's bone‐forming activity and bone‐like tissue production (
Ching‐Yun Chen, Jia‐Ci Jhang, Chun‐Yi Peng, Quốc Cường Nguyễn, Feng‐Huei Lin, Hung‐Ming Wu, Shankung Lin   +6 more
wiley   +1 more source

PROOF IN AN ADMINISTRATIVE PROCEDURE – A SIGNIFICANT SEGMENT OF THE GENERAL PART OF THE ADMINISTRATIVE LAW

Pravo, 2009
The importance of proof in administrative proceedings is arising from the fact that the development of substantive law, a change or termination of any rights is related to the existence or non-existence of relevant facts.
Petar Vukašinović, Igor Šoltes
doaj  

‘Eliminating Conservation’? The Re-Regulation of Hungarian Administrative Procedure in the Act on General Administrative Procedure

AbstractThe chapter analyses the resilience of the general rules of administrative procedural law in Hungary. Traditional doctrinal analysis, historical comparison and the sociology of legislation are applied to show the extent to which legislative transformation reflects the challenges of the socioeconomic environment after 2010.
Balázs, István, Gajduschek, György, Hoffman, István   +2 more
openaire   +3 more sources