Results 71 to 80 of about 990,408 (305)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Informal Action—Adjudication—Rule Making: Some Recent Developments in Federal Administrative Law [PDF]

, 1971
Direct energy consumption of ICT hardware is only “half the story.” In order to get the “whole story,” energy consumption during the entire life cycle has to be taken into account. This chapter is a first step toward a more comprehensive picture, showing
ASG Andrae, B Ness, C Herrmann, DW Pennington, E Müller, E Park, G Rebitzer, I Boustead, J Baliga, JG Koomey, L-T Lu, MAJ Huijbregts, P Teehan, R Frischknecht, R Hischier, R Hischier, RU Ayres, V Coroama, V Coroama, VC Coroama   +19 more
core   +2 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

CURRENT QUESTIONS OF THE REGULATION OF THE NEW CROATIAN GENERAL ADMINISTRATIVE PROCEDURE

Zbornik Radova Pravnog Fakulteta u Splitu, 2008
The authors answer the question of whether Croatia needs a new General Administrative Procedure Act or whether amendment of the existing one is enough.
Boris Ljubanović, Boris Bakota
doaj  

Concept and classification of administrative material actions: Between theory and legislation [PDF]

Zbornik Radova: Pravni Fakultet u Novom Sadu, 2018
This paper deals with the concept of administrative actions and their classification in the Serbian law. With the adoption of the new Law on General Administrative Procedure in 2016, administrative actions have been defined in this Law.
Jovanović Zoran R.
doaj  

The “coactive procedure” in the ecuadorian legislation of the last years (2005-2018), and its regime in the organic administrative code

Revista Facultad de Jurisprudencia, 2018
The coercive procedure refers to the application of the administrative authority with respect to an obligation that citizens or foreigners contract for various circumstances in a given state; Regarding the administrative procedure, several legal bodies ...
Luis Adrian Serrano
doaj   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Objection in the administrative procedure [PDF]

Zbornik Radova: Pravni Fakultet u Novom Sadu, 2018
An objection is a new legal remedy, regulated by the new Law on General Administrative Procedure. Unlike other legal remedies, the objection cannot be used against an administrative act.
Milkov Dragan L., Radošević Ratko S.
doaj  

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source