Results 71 to 80 of about 1,096,189 (267)

The cost associated with the development of the antimicrobial stewardship program in the adult general medicine setting in Qatar

Journal of Pharmaceutical Policy and Practice
To estimate the economic impact of the developed antimicrobial stewardship program (ASP) versus the preliminary ASP use, in the adults' general medicine settings in Qatar.Patient records were retrospectively reviewed during two periods: preliminary ASP was defined as the 12 months following ASP implementation (i.e.
Dina Abushanab, Wafa AL-Marridi, Moza Al Hail, Palli Valappila Abdul Rouf, Wessam ElKassem, Binny Thomas, Hussam Alsoub, Zanfina Ademi, Yolande Hanssens, Rasha El Enany, Daoud Al-Badriyeh   +10 more
openaire   +5 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Quality of life and associated factors among patients with glaucoma attending at Boru Meda General Hospital, Northeast Ethiopia

Scientific Reports
Glaucoma significantly impacts the well-being of millions of people worldwide and contributes to a decline in quality of life. Therefore, this study aimed to evaluate quality of life and identify influencing factors among glaucoma patients receiving care
Hamdu Mohammed, Abebe Tarekegn Kassaw, Fatuma Seid, Samuel Anteneh Ayele   +3 more
doaj   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Executive Summary of the 2024 Philippine Clinical Practice Guidelines on the Diagnosis and Management of Acute Severe Blood Pressure Elevation

The Journal of Clinical Hypertension
A recent survey in the Philippines, PRESYON‐4, showed increasing prevalence of hypertension from 22% in the 1990s to 37% in 2021, of which only 52% were aware of their diagnosis.
Deborah Ignacia D. Ona, Felix Eduardo Punzalan, Raymond V. Oliva, Ma. Sergia Fatima Sucaldito, Noel Espallardo, Richard Santos, Hannah Almenario, Karl Murillo, Valentin Dones III, Elmer Jasper Llanes, Lourdes Ella Santos, Maria Cristina San Jose, Alyssa Samantha Fusingan‐Peralta, Rommel Bataclan, Maria Katrina Mata, Pauline Convocar, Aurelia Leus, Gilbert Vilela   +17 more
doaj   +1 more source

Safety, feasibility and impact of a 12-week yoga program in adults Fontan patients: a pilot study

International Journal of Cardiology Congenital Heart Disease
Background: Reduced exercise capacity and compromised pulmonary function are common findings following Fontan palliation. Although yoga practice has been associated with improved respiratory function in individuals with acquired heart disease, little is ...
Ashish H. Shah, Pradeepkumar Charla, Kohsaku Goto, Purvi A. Shah, Erwin N. Oechslin, John Granton, Rachel M. Wald   +6 more
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

The Interactions between Smoking and Sleep

Biomedicines
Smoking a cigarette before bed or first thing in the morning is a common habit. In this review, the relationship between smoking and sleep is investigated based on the existing literature. Out of 6504 unique items that were identified via a PubMed search
Ioanna Grigoriou, Serafeim-Chrysovalantis Kotoulas, Konstantinos Porpodis, Dionysios Spyratos, Ioanna Papagiouvanni, Alexandros Tsantos, Anastasia Michailidou, Constantinos Mourelatos, Christina Mouratidou, Ioannis Alevroudis, Alexandra Marneri, Athanasia Pataka   +11 more
doaj   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source