Results 81 to 90 of about 1,096,189 (267)

Profile of proinflammatory markers in pregnant women who died of severe COVID-19

Revista Médica del Hospital General de México
Introduction: In December 2019, four cases of pneumonia of unknown origin were reported to the World Health Organization (WHO) in China, caused by SARS-CoV-2. In March 2020, the WHO declared the beginning of the COVID-19 pandemic. In COVID-19, a relevant
Pablo B. Bautista-García, Mariana Bahena-Campos, Diana H. Alcántara-Rosas   +2 more
doaj  

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Can Robotic Arm‐assisted Total Knee Arthroplasty Remain Cost‐effective in Volume‐based Procurement System in China? A Markov Model‐based Study

Orthopaedic Surgery
Objective The volume based procurement (VBP) program in China was initiated in 2022. The cost‐effectiveness of robotic arm assisted total knee arthroplasty is yet uncertain after the initiation of the program.
Zhuo Zhang, Yang Luo, Jing Zhang, Chong Zhang, Xin Wang, Jiying Chen, Wei Chai   +6 more
doaj   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Clinical profile and outcomes of tetanus patients in a tertiary hospital in the Philippines: a ten-year retrospective study

BMC Infectious Diseases
Background Tetanus is a life-threatening but preventable neurologic disorder characterized by trismus and muscle spasms. Despite its decreasing global incidence, it remains to be endemic in resource-limited settings such as the Philippines.
Pamela Danielle T. Lanuza, Jao Jarro B. Garcia, Christian Wilson R. Turalde, Mario Jr. B. Prado   +3 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Reducing asthma attacks in disadvantaged school children with asthma: study protocol for a type 2 hybrid implementation-effectiveness trial (Better Asthma Control for Kids, BACK)

Implementation Science
Background Asthma is a leading cause of children’s hospitalizations, emergency department visits, and missed school days. Our school-based asthma intervention has reduced asthma exacerbations for children experiencing health disparities in the Denver ...
Amy G. Huebschmann, Nicole M. Wagner, Melanie Gleason, John T. Brinton, Michaela Brtnikova, Sarah E. Brewer, Anowara Begum, Rachel Armstrong, Lisa Ross DeCamp, Arthur McFarlane, Heather DeKeyser, Holly Coleman, Monica J. Federico, Stanley J. Szefler, Lisa C. Cicutto   +14 more
doaj   +1 more source

Recognizing familial Huntington's disease in an Asian cohort: Insights from the Philippines

eNeurologicalSci
Huntington's Disease (HD) is an autosomal-dominant, neurodegenerative condition characterized by extrapyramidal, psychiatric, and cognitive disturbances. In the Philippines, only one genetically confirmed sporadic case had been previously reported.
Jao Jarro B. Garcia, Gilbert J. Cabataña, Jr, Iris Ditan, Karl Josef Niño J. Separa, Ida Ingrid Rocha-Tulagan, Han-I Lin, Chin-Hsien Lin, Melanie Leigh D. Supnet-Wells, Alejandro F. Diaz, Arlene R. Ng, Roland Dominic G. Jamora, Gerard Saranza   +11 more
doaj   +1 more source